Human IGFBP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IGFBP1
Locus ID	3484
Kit Components	GA102353G1, IGFBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102353G2, IGFBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102353G3, IGFBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000596, NM_001013029
Synonyms	AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12
Summary	This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]

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