Human IDUA activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IDUA
Locus ID	3425
Kit Components	GA102317G1, IDUA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102317G2, IDUA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102317G3, IDUA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000203, NR_110313, NM_001363576
Synonyms	IDA; MPS1
Summary	This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]

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