Human Bone Sialoprotein (IBSP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IBSP
Locus ID	3381
Kit Components	GA102297G1, Bone Sialoprotein gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102297G2, Bone Sialoprotein gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102297G3, Bone Sialoprotein gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004967
Synonyms	BNSP; BSP; BSP-II; SP-II
Summary	The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

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