Human HYAL1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HYAL1
Locus ID	3373
Kit Components	GA102294G1, HYAL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102294G2, HYAL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102294G3, HYAL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_007312, NM_033159, NM_153281, NM_153282, NM_153283, NM_153284, NM_153285, NM_153286, NR_047690
Synonyms	HYAL-1; LUCA1; MGC45987; NAT6
Summary	This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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