Human 5 HT 2A (HTR2A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HTR2A
Locus ID	3356
Kit Components	GA102284G1, 5 HT 2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102284G2, 5 HT 2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102284G3, 5 HT 2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000621, NM_001165947
Synonyms	5-HT2A; HTR2
Summary	This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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