Human Granzyme H (GZMH) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GZMH
Locus ID	2999
Kit Components	GA102037G1, Granzyme H gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102037G2, Granzyme H gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102037G3, Granzyme H gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001270780, NM_001270781, NM_033423
Synonyms	CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2
Summary	This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]

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