Human Metabotropic Glutamate Receptor 3 (GRM3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GRM3
Locus ID	2913
Kit Components	GA101968G1, Metabotropic Glutamate Receptor 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101968G2, Metabotropic Glutamate Receptor 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101968G3, Metabotropic Glutamate Receptor 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000840, NM_001363522
Synonyms	GLUR3; GPRC1C; mGlu3; MGLUR3
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

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