Human GRB10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GRB10
Locus ID	2887
Kit Components	GA101943G1, GRB10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101943G2, GRB10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101943G3, GRB10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001549, NM_001001550, NM_001001555, NM_005311, NM_001350814, NM_001350815, NM_001350816
Synonyms	Grb-10; GRB-IR; IRBP; MEG1; RSS
Summary	The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

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