Human Glycerol 3 Phosphate Dehydrogenase (GPD1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GPD1
Locus ID	2819
Kit Components	GA101884G1, Glycerol 3 Phosphate Dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101884G2, Glycerol 3 Phosphate Dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101884G3, Glycerol 3 Phosphate Dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001257199, NM_005276
Synonyms	GPD-C; GPDH-C; HTGTI
Summary	This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

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