Human Glutaredoxin 1 (GLRX) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GLRX
Locus ID	2745
Kit Components	GA101832G1, Glutaredoxin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101832G2, Glutaredoxin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101832G3, Glutaredoxin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001118890, NM_001243658, NM_001243659, NM_002064
Synonyms	GRX; GRX1
Summary	This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

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