Human glucose 6 phosphatase, catalytic subunit (G6PC) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	G6PC1
Locus ID	2538
Kit Components	GA101686G1, glucose 6 phosphatase, catalytic subunit gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101686G2, glucose 6 phosphatase, catalytic subunit gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101686G3, glucose 6 phosphatase, catalytic subunit gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000151, NM_001270397
Synonyms	G6PC1; G6PT; GSD1; GSD1a
Summary	Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]

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