Human AFF2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AFF2
Locus ID	2334
Kit Components	GA101640G1, AFF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101640G2, AFF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101640G3, AFF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001169122, NM_001169123, NM_001169124, NM_001169125, NM_001170628, NM_002025
Synonyms	FMR2; FMR2P; FRAXE; MRX2; OX19
Summary	This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]

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