Human Desmoglein 1 (DSG1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DSG1
Locus ID	1828
Kit Components	GA101279G1, Desmoglein 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101279G2, Desmoglein 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101279G3, Desmoglein 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001942
Synonyms	CDHF4; DG1; DSG; EPKHE; EPKHIA; PPKS1; SPPK1
Summary	This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

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