Human Desmocollin 2 (DSC2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DSC2
Locus ID	1824
Kit Components	GA101275G1, Desmocollin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101275G2, Desmocollin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101275G3, Desmocollin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004949, NM_024422
Synonyms	ARVD11; CDHF2; DG2; DGII/III; DSC3
Summary	This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

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