Human DKC1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DKC1
Locus ID	1736
Kit Components	GA101205G1, DKC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101205G2, DKC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101205G3, DKC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142463, NM_001288747, NM_001363, NR_110021, NR_110022, NR_110023
Synonyms	CBF5; DKC; DKCX; NAP57; NOLA4; XAP101
Summary	This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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