Human delta 2 Catenin (CTNND2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CTNND2
Locus ID	1501
Kit Components	GA101062G1, delta 2 Catenin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101062G2, delta 2 Catenin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101062G3, delta 2 Catenin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001288715, NM_001288716, NM_001288717, NM_001332, NR_109988, NM_001364128
Synonyms	GT24; NPRAP
Summary	This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

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