Human CHRND activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CHRND
Locus ID	1144
Kit Components	GA100821G1, CHRND gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100821G2, CHRND gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100821G3, CHRND gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000751, NM_001256657, NM_001311195, NM_001311196, NR_046333, NR_046334
Synonyms	ACHRD; CMS2A; CMS3A; CMS3B; CMS3C; FCCMS; SCCMS
Summary	The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

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