Human CHD3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CHD3
Locus ID	1107
Kit Components	GA100789G1, CHD3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100789G2, CHD3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100789G3, CHD3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001005271, NM_001005273, NM_001272, NM_005852
Synonyms	Mi-2a; Mi2-ALPHA; ZFH
Summary	This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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