Human Cofilin 2 (CFL2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CFL2
Locus ID	1073
Kit Components	GA100774G1, Cofilin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100774G2, Cofilin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100774G3, Cofilin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001243645, NM_021914, NM_138638, NR_028130, NR_028131, NR_028132
Synonyms	NEM7
Summary	This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

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