Human Caspase 2 (CASP2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CASP2
Locus ID	835
Kit Components	GA100588G1, Caspase 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100588G2, Caspase 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100588G3, Caspase 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001224, NM_032982, NM_032983, NM_032984
Synonyms	CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

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