Human bcl 6 (BCL6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BCL6
Locus ID	604
Kit Components	GA100415G1, bcl 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100415G2, bcl 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100415G3, bcl 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001130845, NM_001134738, NM_001706, NM_138931
Synonyms	BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Summary	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

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