Human BCAT1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BCAT1
Locus ID	586
Kit Components	GA100404G1, BCAT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100404G2, BCAT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100404G3, BCAT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001178091, NM_001178092, NM_001178093, NM_001178094, NM_005504
Synonyms	BCATC; BCT1; ECA39; MECA39; PNAS121; PP18
Summary	This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

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