Human AIRE activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AIRE
Locus ID	326
Kit Components	GA100227G1, AIRE gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100227G2, AIRE gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100227G3, AIRE gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000383, NM_000658, NM_000659
Synonyms	AIRE1; APECED; APS1; APSI; PGA1
Summary	This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

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