Human ALAS1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ALAS1
Locus ID	211
Kit Components	GA100146G1, ALAS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100146G2, ALAS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100146G3, ALAS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000688, NM_001304443, NM_001304444, NM_199166
Synonyms	ALAS; ALAS-H; ALAS3; ALASH; MIG4
Summary	This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

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