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Thoc5 (NM_001012153) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR201699L3V
- LentiORF®
-
Lenti ORF particles, Thoc5 (Myc-DDK-tagged ORF) - Rat THO complex 5 (Thoc5), 200ul, >10^7 TU/mL
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CNY 11,590.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Thoc5 (NM_001012153) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | Fmip |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001012153 |
| ORF Size | 2046 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR201699).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001012153.1, NP_001012153.1 |
| RefSeq Size | 2227 bp |
| RefSeq ORF | 2049 bp |
| Locus ID | 360972 |
| Gene Summary | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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THOC2 and THOC5 Regulate Stemness and Radioresistance in Triple‐Negative Breast Cancer
,null,
Advanced Science
,PubMed ID 34708581
[Thoc5]
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