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SKA2 (NM_001100595) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC222296L4V
- LentiORF®
-
Lenti ORF particles, SKA2 (mGFP-tagged) - Human spindle and kinetochore associated complex subunit 2 (SKA2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | SKA2 (NM_001100595) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | FAM33A |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001100595 |
| ORF Size | 225 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC222296).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001100595.1 |
| RefSeq Size | 2988 bp |
| RefSeq ORF | 228 bp |
| Locus ID | 348235 |
| MW | 8.1 kDa |
| Gene Summary | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).[UniProtKB/Swiss-Prot Function] |
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