elF2 alpha (EIF2S1) (NM_004094) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC200368L3V
- LentiORF®
Lenti ORF particles, EIF2S1 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1), 200ul, >10^7 TU/mL
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CNY 8,170.00
Cited in 1 publication. |
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CNY 1,999.00
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Specifications
Product Data | |
Product Name | elF2 alpha (EIF2S1) (NM_004094) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_004094 |
ORF Size | 945 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC200368).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_004094.4 |
RefSeq Size | 4165 bp |
RefSeq ORF | 948 bp |
Locus ID | 1965 |
Domains | S1 |
MW | 36.1 kDa |
Gene Summary | The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis
,Bai, X;Ni, J;Beretov, J;Wasinger, V;Wang, S;Zhu, Y;Graham, P;Li, Y;,
Redox Biology
,PubMed ID 33946018
[EIF2S1]
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