Ythdf3 (BC057158) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209195L4V
- LentiORF®
-
Lenti ORF particles, Ythdf3 (GFP-tagged) - Mouse YTH domain family 3 (cDNA clone MGC:67692 IMAGE:5348717), 200ul, >10^7 TU/mL
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CNY 11115.00
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Specifications
| Product Data | |
| Product Name | Ythdf3 (BC057158) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9130022A11Rik |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC057158 |
| ORF Size | 1767 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209195).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC057158, AAH57158 |
| RefSeq Size | 3173 bp |
| RefSeq ORF | 1769 bp |
| Locus ID | 229096 |
| Gene Summary | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A-containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits (By similarity). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs and promoting their translation (PubMed:30591559). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (PubMed:30591559). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (By similarity). Recognizes and binds m6A-containing circular RNAs (circRNAs) and promotes their translation (By similarity). circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (By similarity).[UniProtKB/Swiss-Prot Function] |
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