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Hsf1 (NM_008296) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208087L1V
- LentiORF®
-
Lenti ORF particles, Hsf1 (Myc-DDK-tagged) - Mouse heat shock factor 1 (Hsf1), 200ul, >10^7 TU/mL
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CNY 9,500.00
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Specifications
| Product Data | |
| Product Name | Hsf1 (NM_008296) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AA960185; Hsf1alpha; Hsf1beta; HSTF |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_008296 |
| ORF Size | 1509 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208087).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008296.2 |
| RefSeq Size | 2018 bp |
| RefSeq ORF | 1512 bp |
| Locus ID | 15499 |
| Gene Summary | Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner.[UniProtKB/Swiss-Prot Function] |
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