NLRP11 (NM_001297743) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CLR19.6; NALP11; NOD17; PAN10; PYPAF6; PYPAF7
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001297743, the custom clone sequence may differ by one or more nucleotides ATGAGGAGAAAATTCATGCTGCAATGGGAAAGTCACACTTTTGGAAAATTTCATTATAAATTTTTTCGTG ACGTTTCGTCAGATGTGTTCTACATACTTCAATTAGCCTATGATTCTACCAGCTATTATTCAGCAAACAA TCTCAATGTGTTCCTGATGGGAGAGAGAGCATCTGGAAAAACTATTGTTATAAATCTGGCTGTGTTGAGG TGGATCAAGGGTGAGATGTGGCAGAACATGATCTCGTACGTCGTTCACCTCACTGCTCACGAAATAAACC AGATGACCAACAGCAGCTTGGCTGAGCTAATCGCCAAGGACTGGCCTGACGGCCAGGCTCCCATTGCAGA CATCCTGTCTGATCCCAAGAAACTCCTTTTCATCCTCGAGGACTTGGACAACATAAGATTCGAGTTAAAT GTCAATGAAAGTGCTTTGTGTAGTAACAGCACCCAGAAAGTTCCCATTCCAGTTCTCCTGGTCAGTTTGC TGAAGAGAAAAATGGCTCCAGGCTGCTGGTTCCTCATCTCCTCAAGGCCCACACGTGGGAATAATGTAAA AACGTTCTTGAAAGAGGTAGATTGCTGCACGACCTTGCAGCTGTCGAATGGGAAGAGGGAGATATATTTT AACTCTTTCTTTAAAGACCGCCAGAGGGCGTCGGCAGCCCTCCAGCTTGTACATGAGGATGAAATACTCG TGGGTCTGTGCCGAGTCGCCATCTTATGCTGGATCACGTGTACTGTCCTGAAGCGGCAGATGGACAAGGG GCGTGACTTCCAGCTCTGCTGCCAAACACCCACTGATCTACATGCCCACTTTCTTGCTGATGCGTTGACA TCAGAGGCTGGACTTACTGCCAATCAGTATCACCTAGGTCTCCTAAAACGTCTGTGTTTGCTGGCTGCAG GAGGACTGTTTCTGAGCACCCTGAATTTCAGTGGTGAAGACCTCAGATGTGTTGGGTTTACTGAGGCTGA TGTCTCTGTGTTGCAGGCCGCGAATATTCTTTTGCCGAGCAACACTCATAAAGACCGTTACAAGTTCATA CACTTGAACGTCCAGGAGTTTTGTACAGCCATTGCATTTCTGATGGCAGTACCCAACTATCTGATCCCCT CAGGCAGCAGAGAGTATAAAGAGAAGAGAGAACAATACTCTGACTTTAATCAAGTGTTTACTTTCATTTT TGGTCTTCTAAATGCAAACAGGAGAAAGATTCTTGAGACATCCTTTGGATACCAGCTACCGATGGTAGAC AGCTTCAAGTGGTACTCGGTGGGATACATGAAACATTTGGACCGTGACCCGGAAAAGTTGACGCACCATA TGCCTTTGTTTTACTGTCTCTATGAGAATCGGGAAGAAGAATTTGTGAAGACGATTGTGGATGCTCTCAT GGAGGTTACAGTTTACCTTCAATCAGACAAGGATATGATGGTCTCATTATACTGTCTGGATTACTGCTGT CACCTGAGGACACTTAAGTTGAGTGTTCAGCGCATCTTTCAAAACAAAGAGCCACTTATAAGGCCAACTG CTAGTCAAATGAAGAGCCTTGTCTACTGGAGAGAGATCTGCTCTCTTTTTTATACAATGGAGAGCCTCCG GGAGCTGCATATCTTTGACAATGACCTTAATGGTATTTCAGAAAGGATTCTGTCTAAAGCCCTGGAGCAT TCTAGCTGTAAACTTCGCACACTCAAGTTGTCCTATGTCTCGACTGCTTCTGGTTTTGAAGACTTACTCA AGGCTTTGGCTCGTAATCGGAGCCTGACATACCTGAGTATCAACTGTACGTCCATTTCCCTAAATATGTT TTCACTTCTGCATGACATCCTGCACGAGCCCACATGCCAAATAAGTCATCTGAGCTTGATGAAATGTGAT TTGCGAGCCAGCGAATGTGAAGAAATCGCCTCTCTCCTCATCAGTGGCGGGAGTCTGAGAAAACTGACCT TATCCAGCAATCCGCTGAGGAGCGACGGGATGAACATACTGTGTGATGCCTTGCTTCATCCCAACTGCAC TCTTATATCACTGGTGTTAGTCTTCTGCTGTCTCACTGAAAATTGCTGCAGCGCCCTTGGAAGAGTGCTT CTGTTCAGCCCAACTCTAAGACAACTAGACCTGTGTGTGAATCGCTTAAAAAATTACGGAGTGTTGCATG TGACGTTTCCCTTGCTGTTTCCAACCTGTCAGTTAGAGGAGCTTCATCTGTCTGGCTGTTTCTTTAGCAG CGATATCTGTCAATATATTGCCATAGTTATTGCTACTAATGAAAAACTGAGGAGCCTGGAGATTGGGAGC AACAAAATAGAAGATGCAGGAATGCAGCTGCTATGTGGTGGTTTGAGACATCCCAACTGCATGTTGGTGA ATATTGGGCTAGAAGAGTGCATGTTAACCAGTGCCTGCTGTCGATCTCTTGCCTCTGTTCTTACCACCAA CAAAACACTAGAAAGACTCAACTTGCTTCAAAATCACTTGGGCAATGATGGAGTTGCAAAACTTCTTGAG AGCTTGATCAGCCCAGATTGTGTACTTAAGGTAGTTGGGCTTCCATTAACTGGCCTGAACACACAAACCC AGCAGTTGCTGATGACTGTAAAGGAAAGAAAACCCAGTTTGATCTTTCTGTCTGAAACTTGGTCTTTAAA GGAAGGCAGAGAAATTGGTGTGACACCTGCTTCTCAGCCAGGTTCAATAATACCTAATTCTAATTTGGAT TACATGTTTTTCAAATTTCCCAGAATGTCTGCAGCCATGAGAACGTCAAATACAGCATCTAGGCAACCCC TTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001297743
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001297743.1, NP_001284672.1
RefSeq Size	3209 bp
RefSeq ORF	2805 bp
Locus ID	204801
UniProt ID	P59045
Protein Families	Druggable Genome
Gene Summary	This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017] Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

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