Lipin 3 (LPIN3) (NM_001301860) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	dJ620E11.2; LIPN3L; SMP2
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001301860, the custom clone sequence may differ by one or more nucleotides ATGAACTACGTGGGGCAGCTGGCGGAGACGGTGTTTGGGACGGTGAAGGAGCTGTACCGGGGCCTGAACC CAGCCACACTGAGCGGCGGCATTGACGTGCTGGTGGTGAAGCAGGTGGACGGCTCGTTCCGGTGCTCACC CTTCCACGTGCGTTTTGGCAAGCTGGGCGTCCTGCGGTCGCGGGAGAAGGTGGTAGACATTGAGCTCAAT GGGGAGCCTGTGGACTTGCACATGAAGCTTGGGGACAGCGGGGAGGCCTTCTTTGTTCAGGAGCTGGAGA GCGATGATGAACATGTGCCTCCCGGCCTGTGCACCTCACCCATCCCTTGGGGGGGTCTGTCTGGCTTCCC CTCGGACTCCCAGCTGGGCACTGCCAGTGAGCCTGAGGGCCTCGTCATGGCAGGCACGGCCTCCACTGGG CGGAGGAAGAGGCGTCGCAGGAGGAAACCCAAGCAGAAAGAGGATGCAGTGGCAACTGATTCTAGTCCAG AGGAACTGGAGGCAGGCGCTGAGAGTGAGCTATCCCTGCCGGAAAAGCTGAGGCCAGAGCCCCCAGGCAG TGTCCAGTTGGAAGAGAAGTCTTCACTGCAGCCCAAAGACATCTACCCCTACTCGGATGGCGAGTGGCCC CCCCAGGCCAGCCTCTCAGCAGGTGAGCTAACATCCCCTAAGAGCGACTCGGAGCTGGAGGTGCGGACCC CGGAGCCCAGTCCCCTAAGAGCCGAGTCCCACATGCAGTGGGCCTGGGGGAGGCTGCCTAAGGTGGCCAG AGCTGAGCGGCCCGAGTCCTCAGTGGTCCTTGAAGGCAGAGCTGGGGCAACCTCTCCTCCTCGGGGAGGA CCCAGCACTCCCTCTACCTCTGTGGCTGGCGGCGTGGACCCTTTGGGACTCCCAATCCAGCAAACAGAGG CTGGTGCCGACCTTCAGCCTGACACAGAGGATCCCACTCTAGTGGGTCCCCCTCTCCACACCCCAGAGAC AGAGGAAAGCAAGACTCAGAGCTCTGGGGACATGGGCCTCCCTCCTGCCTCCAAGTCATGGAGCTGGGCC ACTCTGGAGGTTCCAGTTCCCACCGGGCAGCCAGAGAGGGTCTCCAGGGGGAAAGGCTCCCCAAAGAGAA GCCAGCACCTGGGCCCCAGTGACATCTACCTGGATGACTTGCCCTCCCTGGACTCTGAGAATGCAGCGCT TTACTTCCCCCAAAGTGACTCTGGGCTGGGGGCCAGAAGATGGAGTGAACCCAGCAGTCAGAAGTCCCTG AGGGACCCCAACCCTGAACATGAACCTGAACCCACTCTGGACACAGTGGATACAATAGCACTGTCCCTCT GTGGTGGACTGGCTGACAGCCGGGACATCTCCCTAGAGAAATTCAACCAGCACAGCGTCTCTTACCAGGA CCTCACCAAAAACCCCGGACTTTTGGATGACCCAAACCTAGTGGTGAAAATCAATGGAAAGCATTATAAC TGGGCTGTGGCTGCCCCCATGATCCTCTCCCTGCAAGCCTTCCAGAAAAACTTGCCCAAGAGCACCATGG ACAAGCTGGAGAGGGAGAAGATGCCCCGGAAGGGTGGGCGATGGTGGTTTTCCTGGCGACGCAGGGACTT CCTGGCCGAGGAGCGCAGTGCCCAGAAGGAGAAGACTGCAGCCAAGGAGCAGCAGGGGGAGAAGACAGAA GTCCTGAGCAGTGATGACGATGCCCCAGACAGCCCTGTGATCCTGGAGATCCCCTCCTTGCCACCCTCCA CTCCACCCTCCACTCCTACCTACAAGAAGTCCCTCCGCCTCTCCTCCGATCAGATCCGGCGCCTGAACCT GCAAGAAGGTGCCAATGATGTGGTCTTCAGCGTGACCACTCAGTACCAGGGCACCTGCCGCTGCAAGGCC ACCATCTACCTGTGGAAATGGGACGACAAGGTGGTCATCTCTGACATCGACGGCACCATCACCAAGTCAG ATGCTCTGGGCCATATCCTGCCCCAGCTGGGGAAAGACTGGACACACCAGGGCATCACCAGTCTCTATCA CAAAATCCAACTAAATGGGTACAAGTTCCTGTACTGCTCGGCGCGGGCCATTGGCATGGCGGACCTCACC AAGGGGTACCTGCAGTGGGTGAGCGAGGGGGGCTGTAGCCTCCCCAAGGGCCCCATCCTTCTGTCTCCCA GCAGCCTCTTCTCTGCCCTCCACAGAGAGGTGATCGAGAAGAAACCAGAGGTGTTCAAGGTCGCCTGCCT GAGTGACATCCAGCAGCTGTTTCTGCCCCACGGACAGCCCTTCTATGCTGCCTTTGGGAATAGGCCCAAT GATGTCTTTGCCTACCGGCAGGTGGGCCTGCCTGAGTCACGCATCTTCACAGTCAACCCCCGGGGAGAGC TCATCCAGGAGCTCATAAAGAACCACAAATCCACGTATGAGCGGCTTGGTGAAGTGGTCGAGCTCCTCTT CCCACCTGTGGCCCGTGGCCCCAGCACAGACCTGGCCAACCCTGAATACAGTAACTTCTGCTACTGGCGG GAGCCACTGCCTGCTGTGGACCTTGATACCCTGGACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001301860
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001301860.1, NP_001288789.1
RefSeq Size	4463 bp
RefSeq ORF	2559 bp
Locus ID	64900
UniProt ID	Q9BQK8
Gene Summary	The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.

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