TMEM106A (NM_001291586) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Vector	pCMV6 series
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001291586, the custom clone sequence may differ by one or more nucleotides ATGGGTAAGACGTTTTCCCAGCTGGGCTCTTGGCGGGAGGATGAGAACAAGTCAATCCTGTCCTCCAAAC CAGCCATTGGCAGCAAGGCTGTCAACTACTCCAGCACCGGTAGCAGCAAGTCTTTTTGTTCCTGTGTGCC TTGTGAAGGAACTGCTGATGCCAGCTTCGTGACTTGTCCCACCTGCCAGGGCAGTGGCAAGATTCCCCAA GAGCTGGAGAAGCAGTTGGTGGCTCTCATTCCCTATGGGGACCAGAGGCTGAAGCCCAAGCACACGAAGC TCTTTGTGTTCCTGGCCGTGCTCATCTGCCTGGTGACCTCCTCCTTCATCGTCTTTTTCCTGTTTCCCCG GTCCGTCATTGTGCAGCCTGCAGGCCTCAACTCCTCCACAGTGGCCTTTGATGAGGCTGATATCTACCTC AACATAACGAATATCTTAAACATCTCCAATGGCAACTACTACCCCATTATGGTGACACAGCTGACCCTCG AGGTTCTGCACCTGTCCCTCGTGGTGGGGCAGGTTTCCAACAACCTTCTCCTACACATTGGCCCTTTGGC CAGTGAACAGATGTTTTACGCAGTAGCTACCAAGATACGGGATGAAAACACATACAAAATCTGTACCTGG CTGGAAATCAAAGTCCACCATGTGCTTTTGCACATCCAGGGCACCCTGACCTGTTCATACCTGAGCCATT CAGAGCAGCTGGTCTTTCAGAGCTATGAATATGTGGACTGCCGAGGAAACGCATCTGTGCCCCACCAGCT GACCCCTCACCCACCATGA
Restriction Sites	SgfI-MluI
ACCN	NM_001291586
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001291586.1, NP_001278515.1
RefSeq Size	3348 bp
RefSeq ORF	789 bp
Locus ID	113277
UniProt ID	Q96A25
Protein Families	Transmembrane
Gene Summary	Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:30456879, PubMed:29131025).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.