ALDH1L1 (NM_001270365) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	10-fTHF; 10-FTHFDH; FDH; FTHFD
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330809 representing NM_001270365. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGAAGATTGCAGTGATTGGACAGAGCCTGTTTGGCCAGGAAGTTTACTGCCACCTGAGGAAGGAGGGC CACGAAGTGGTGGGTGTGTTCACTGTTCCAGACAAGGATGGAAAGGCCGACCCCCTGGGTCTGGAAGCT GAGAAGGATGGAGTGCCGGTATTCAAGTACTCCCGGTGGCGTGCAAAAGGACAGGCTTTGCCTGATGTG GTGGCAAAATACCAGGCTTTGGGGGCCGAGCTCAACGTCCTGCCCTTCTGCAGCCAATTCATCCCCATG GAGATAATCAGTGCCCCCCGGCATGGCTCCATCATCTATCACCCGTCACTGCTCCCTAGGCACCGAGGG GCCTCGGCCATTCACAACTGGATCCGCGGGAACGACAAGGTGCCGGGAGCCTGGACAGAGGCCTGTGAA CAGAAACTGACATTTTTCAACTCAACGCTGAACACTTCAGGCCTGGTGCCCGAGGGAGACGCTTTGCCC ATCCCAGGAGCCCATCGGCCAGGGGTGGTCACCAAAGCAGGACTCATCCTCTTTGGGAATGATGACAAA ATGCTGCTGGTGAAGAATATTCAGCTGGAGGATGGCAAAATGATCCTGGCCTCGAACTTCTTTAAGGGG GCAGCCAGCAGTGTCCTTGAGCTGACAGAGGCAGAGCTGGTTACTGCGGAGGCTGTGCGGAGTGTTTGG CAGCGGATCCTCCCCAAAGTCCTGGAGGTTGAAGACTCCACTGATTTCTTCAAGTCAGGGGCCGCGTCT GTGGACGTTGTGAGGCTGGTGGAGGAAGTGAAGGAGCTGTGTGATGGCCTGGAGTTAGAAAATGAAGAT GTGTACATGGCATCCACCTTTGGGGACTTCATCCAGCTGTTAGTGAGGAAGCTGCGAGGGGACGATGAG GAGGGCGAGTGCAGCATTGACTACGTGGAAATGGCAGTGAACAAGCGCACTGTCCGCATGCCCCACCAG CTCTTCATTGGGGGGGAGTTCGTGGATGCCGAGGGCGCCAAGACCTCTGAGACCATCAATCCCACCGAT GGAAGTGTCATCTGCCAGGTATCCCTGGCCCAAGTCACCGACGTCGACAAGGCAGTGGCCGCAGCCAAG GATGCCTTTGAGAATGGACGGTGGGGGAAGATCAGTGCGCGGGACCGGGGCCGGCTGATGTACAGGTTG GCAGATCTCATGGAGCAGCACCAGGAGGAGCTGGCCACCATTGAGGCCCTGGATGCGGGTGCCGTCTAC ACGCTGGCCCTGAAGACCCACGTGGGCATGTCCATCCAGACCTTCCGCTACTTTGCTGGCTGGTGTGAC AAGATCCAGGGCTCCACCATCCCCATCAACCAGGCCAGACCCAACCGCAACCTGACCTTGACCAGGAAG GAGCCTGTTGGGGTTTGTGGCATCATCATCCCCTGGAACTATCCCCTGATGATGCTGTCCTGGAAGACA GCTGCCTGCCTGGCTGCCGGGAACACAGTGGTGATCAAGCCTGCTCAGGTGACCCCACTCACAGCCTTG AAGTTTGCAGAGCTGACATTAAAGGCCGGCATTCCCAAAGGTGTGGTTAACGTCCTCCCAGGATCTGGC TCCCTGGTCGGCCAGAGACTCTCAGACCATCCTGATGTGAGGAAAATCGGGTTCACAGGCTCCACAGAG GTGGGCAAGCACATCATGAAAAGCTGTGCCATAAGTAACGTGAAGAAGGTGTCCCTGGAACTGGGCGGG AAGTCACCCCTCATCATCTTTGCTGACTGTGACCTCAACAAGGCTGTGCAGATGGGGATGAGTTCTGTT TTCTTCAACAAAGGAGAGAATTGCATTGCAGCAGGCCGACTCTTTGTGGAGGACTCCATTCATGATGAG TTCGTGCGGAGAGTGGTAGAAGAGGTGCGGAAGATGAAGGTGGGCAACCCGCTGGACAGGGACACCGAC CACGGGCCGCAGAATCACCATGCCCACCTTGTGAAGCTGATGGAGTACTGCCAGCATGGCGTGAAGGAA GGGGCCACACTGGTCTGCGGCGGGAATCAGGTCCCTCGGCCAGGGTTCTTCTTTGAGCCAACTGTTTTC ACAGACGTGGAAGACCACATGTTCATAGCCAAGGAGGAGTCCTTCGGGCCTGTCATGATCATCTCTCGG TTTGCTGATGGGGACTTGGATGCCGTGCTGTCTCGGGCCAATGCCACGGAATTTGGCCTGGCTTCTGGT GTCTTCACCAGGGACATCAACAAGGCCCTGTATGTCAGTGACAAGCTCCAGGCAGGCACTGTGTTTGTC AACACGTACAACAAGACCGACGTGGCCGCTCCCTTCGGAGGATTCAAACAGTCTGGATTTGGCAAAGAT CTAGGAGAGGCGGCTCTGAACGAGTACCTGCGGGTCAAGACAGTGACCTTCGAATACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001270365
Insert Size	2406 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001270365.1
RefSeq Size	3003 bp
RefSeq ORF	2406 bp
Locus ID	10840
UniProt ID	O75891
Protein Families	Druggable Genome
Protein Pathways	One carbon pool by folate
MW	87.6 kDa
Gene Summary	The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Transcript Variant: This variant (3) differs in the both the 5' UTR and the coding sequence, but maintains the reading frame, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.

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