TANK (NM_001199135) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	I-TRAF; ITRAF; TRAF2
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC329485 representing NM_001199135. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGATAAAAACATTGGCGAGCAACTCAATAAAGCGTATGAAGCCTTCCGGCAGGCATGCATGGATAGA GATTCTGCAGTAAAAGAATTACAGCAAAAGACTGAGAACTATGAGCAGAGAATACGTGAACAACAGGAA CAGCTGTCACTTCAACAGACTATTATTGACAAGCTAAAATCTCAGTTACTTCTTGTGAATTCCACTCAA GATAACAATTATGGCTGTGTTCCTCTGCTTGAAGACAGTGAAACAAGAAAGAATAATTTGACTCTTGAT CAGCCACAAGATAAAGTGATTTCAGGAATAGCAAGAGAAAAACTACCAAAGGTAAGAAGACAAGAGGTT TCTTCTCCTAGAAAAGAAACTTCAGCAAGGAGTCTTGGCAGTCCTTTGCTCCATGAAAGGGGTAATATA GAGAAGACTTTCTGGGATCTGAAAGAAGAATTTCATAAAATATGCATGCTAGCAAAAGCACAGAAAGAC CACTTAAGCAAACTTAATATACCAGACACTGCAACTGAAACACAGTGCTCTGTGCCTATACAGTGTACG GATAAAACAGATAAACAAGAAGCGCTGTTTAAGCCTCAGGCTAAAGATGATATAAATAGAGGTGCACCA TCCATCACATCTGTCACACCAAGAGGACTGTGCAGAGATGAGGAAGACACCTCTTTTGAATCACTTTCT AAATTCAATGTCAAGTTTCCACCTATGGACAATGACTCAACTTTCTTACATAGCACTCCAGAGAGACCC GGCATCCTTAGTCCTGCCACGTCTGAGGCAGTGTGCCAAGAGAAATTTAATATGGAGTTCAGAGACAAC CCAGGGAACTTTGTTAAAACAGAAGAAACTTTATTTGAAATTCAGGGAATTGACCCCATAGCTTCAGCT ATACAAAACCTTAAAACAACTGACAAAACAAAGCCCTCAAATCTCGTAAACACTTGTATCAGGACAACT CTGGATAGAGCTGCGTGTTTGCCACCTGGAGACCATAATGCATTATATGTAAATAGCTTCCCACTTCTG GACCCATCTGATGCACCTTTTCCCTCACTCGATTCCCCGGGAAAAGCAATCCGAGGACCACAGCAGCCC ATTTGGAAGCCCTTTCCTAATCAAGACAGTGACTCGGTGGTACTAAGTGGCACAGACTCAGAACTGCAT ATACCTCGAGTATGTGAATTCTGTCAAGCAGTTTTCCCACCATCCATTACATCCAGGGGGGATTTCCTT CGGCATCTTAATTCACACTTCAATGGAGAGACTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001199135
Insert Size	1278 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001199135.1
RefSeq Size	2060 bp
RefSeq ORF	1278 bp
Locus ID	10010
UniProt ID	Q92844
Protein Families	Druggable Genome
Protein Pathways	RIG-I-like receptor signaling pathway
MW	47.8 kDa
Gene Summary	The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Transcript Variant: This variant (3) has an alternate 5' UTR exon compared to variant 1. Variants 1 and 2 encode the same isoform (a).

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