LRRC8B (NM_001134476) Human Untagged Clone
CAT＃: SC325336
LRRC8B (untagged)-Human leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2
CNY 7220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | TA-LRRP; TALRRP |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001134476, the custom clone sequence may differ by one or more nucleotides
ATGATTACACTAACTGAGCTAAAATGCTTAGCAGATGCCCAGTCATCTTATCACATCTTA AAACCATGGTGGGACGTCTTCTGGTATTACATCACACTGATCATGCTGCTGGTGGCCGTG CTGGCCGGAGCTCTCCAGCTGACGCAGAGCAGGGTTCTGTGCTGTCTTCCATGCAAAGTG GAATTTGACAATCACTGTGCCGTGCCTTGGGACATCCTGAAAGCCAGCATGAACACATCC TCTAATCCTGGGACACCGCTTCCGCTCCCCCTCCGAATTCAGAATGACCTCCACCGACAG CAGTACTCCTATATTGATGCCGTCTGTTACGAGAAACAGCTCCATTGGTTTGCAAAGTTT TTCCCCTATCTGGTGCTCTTGCACACGCTCATCTTTGCAGCCTGCAGCAACTTTTGGCTT CACTACCCCAGTACCAGTTCCAGGCTCGAGCATTTTGTGGCCATCCTTCACAAGTGCTTC GATTCTCCATGGACCACCCGCGCCCTTTCAGAAACAGTGGCTGAGCAGTCAGTGAGGCCT CTGAAACTCTCCAAGTCCAAGATTTTGCTTTCGTCCTCAGGGTGTTCAGCTGACATAGAT TCCGGCAAACAGTCATTGCCCTACCCACAGCCAGGTTTGGAGTCAGCTGGCATAGAAAGC CCAACTTCCAGTGTCCTGGACAAGAAGGAGGGTGAACAGGCCAAAGCCATCTTTGAAAAA GTGAAAAGATTCCGCATGCATGTGGAGCAGAAGGACATCATTTATAGAGTATATCTGAAA CAGATAATAGTCAAAGTCATTTTGTTTGTGCTCATCATAACTTATGTTCCATATTTTTTA ACCCACATCACTCTTGAAATCGACTGTTCAGTTGATGTGCAGGCTTTTACAGGATATAAG CGCTACCAGTGTGTCTATTCCTTGGCAGAAATCTTTAAGGTCCTGGCTTCATTTTATGTC ATTTTGGTTATACTTTATGGTCTGACCTCTTCCTACAGCCTGTGGTGGATGCTGAGGAGT TCCCTGAAGCAATATTCCTTTGAGGCGTTAAGAGAAAAAAGCAACTACAGTGACATCCCT GATGTCAAGAATGACTTTGCCTTCATCCTTCATCTGGCTGATCAGTATGATCCTCTTTAT TCCAAACGCTTCTCCATATTCCTATCAGAGGTCAGTGAGAACAAACTGAAACAGATCAAC CTCAATAATGAATGGACAGTTGAGAAACTGAAAAGTAAGCTTGTGAAAAATGCCCAGGAC AAGATAGAACTGCATCTTTTTATGCTCAACGGTCTTCCAGACAATGTCTTTGAGTTAACT GAAATGGAAGTGCTAAGCCTGGAGCTTATCCCAGAGGTGAAGCTGCCCTCTGCAGTCTCA CAGCTGGTCAACCTCAAGGAGCTTCGTGTGTACCATTCATCTCTGGTCGTAGACCATCCT GCACTGGCCTTTCTAGAGGAGAATTTAAAAATCCTCCGCCTGAAATTTACTGAAATGGGA AAAATCCCACGCTGGGTATTTCACCTCAAGAATCTCAAGGAACTTTATCTTTCGGGCTGT GTTCTCCCTGAACAGTTGAGTACTATGCAGTTGGAGGGCTTTCAGGACTTAAAAAATCTA AGGACCCTGTACTTGAAGAGCAGCCTCTCCCGGATCCCACAAGTTGTTACAGACCTCCTG CCTTCATTGCAGAAACTGTCCCTTGATAATGAGGGAAGCAAACTGGTTGTGTTGAACAAC TTGAAAAAGATGGTCAATCTGAAAAGCCTAGAACTGATCAGCTGTGACCTGGAACGCATC CCACATTCCATTTTCAGCCTGAATAATTTGCATGAGTTAGACCTAAGGGAAAATAACCTT AAAACTGTGGAAGAGATCATTAGCTTTCAGCATCTTCAGAATCTTTCCTGCTTAAAGTTG TGGCACAATAACATTGCTTATATTCCTGCACAGATTGGGGCATTATCTAACCTAGAGCAG CTCTCTTTGGACCATAATAATATTGAGAATCTGCCCTTGCAGCTTTTCCTATGCACTAAA CTACATTATTTGGATCTAAGCTATAACCACTTGACCTTCATTCCAGAAGAAATCCAGTAT CTGAGTAATTTGCAGTACTTTGCTGTGACCAACAACAATATTGAGATGCTACCAGATGGG CTGTTTCAGTGCAAAAAGCTGCAGTGTTTACTTTTGGGGAAAAATAGCTTGATGAATTTG TCCCCTCATGTGGGTGAGCTGTCAAACCTTACTCATCTGGAGCTCATTGGTAATTACCTG GAAACACTTCCTCCTGAACTAGAAGGATGTCAGTCCCTAAAACGGAACTGTCTGATTGTT GAGGAGAACTTGCTCAATACTCTTCCTCTCCCTGTAACAGAACGTTTACAGACGTGCTTA GACAAATGT |
| Restriction Sites | Please inquire |
| ACCN | NM_001134476 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001134476.1, NP_001127948.1 |
| RefSeq Size | 7766 bp |
| RefSeq ORF | 2412 bp |
| Locus ID | 23507 |
| UniProt ID | Q6P9F7 |
| Protein Families | Transmembrane |
| Gene Summary | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226175 | LRRC8B (Myc-DDK-tagged)-Human leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2 |
CNY 3990.00 |
|
| RC226175L3 | Lenti-ORF clone of LRRC8B (Myc-DDK-tagged)-Human leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2 |
CNY 5890.00 |
|
| RC226175L4 | Lenti-ORF clone of LRRC8B (mGFP-tagged)-Human leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2 |
CNY 5890.00 |
|
| RG226175 | LRRC8B (tGFP-tagged) - Human leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2 |
CNY 4370.00 |
