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Activin A Receptor Type IC (ACVR1C) (NM_145259) Human Untagged Clone
CAT＃: SC323474
ACVR1C (untagged)-Kinase deficient mutant (K142M) of Human activin A receptor, type IC (ACVR1C), transcript variant 1
CNY 3,656.00
CNY 7,220.00
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ACVRLK7; ALK7 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_145259, the custom clone sequence may differ by one or more nucleotides
ATGACCCGGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGC CAGGACTGAAGTGTGTATGTCTTTTGTGTGATTCTTCAAACTTTACCTGCCAAACAGAAGGAGCATGTTG GGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCTGTGTCTCCCTTCCAGAACTGAAT GCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCAACA ACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAAAACTTGGACCCATGGAGCTGGCCATCAT TATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGGGTCGACAG TGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTG GAAAAACTCTGAAAGATCTGATTTATGATGTGACCGCCTCTGGATCTGGCTCTGGTCTACCTCTGTTGGT TCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTGG CATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGTTTC GTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAA CAAAGATAATGGAACTTGGACTCAACTTTGGCTGGTATCTGAATATCATGAACAGGGCTCCTTATATGAC TATTTGAATAGAAATATAGTGACCGTGGCTGGAATGATCAAGCTGGCGCTCTCAATTGCTAGTGGTCTGG CACACCTTCATATGGAGATTGTTGGTACACAAGGTAAACCTGCTATTGCTCATCGAGACATAAAATCAAA GAATATCTTAGTGAAAAAGTGTGAAACTTGTGCCATAGCGGACTTAGGGTTGGCTGTGAAGCATGATTCA ATACTGAACACTATCGACATACCTCAGAATCCTAAAGTGGGAACCAAGAGGTATATGGCTCCTGAAATGC TTGATGATACAATGAATGTGAATATCTTTGAGTCCTTCAAACGAGCTGACATCTATTCTGTTGGTCTGGT TTACTGGGAAATAGCCCGGAGGTGTTCAGTCGGAGGAATTGTTGAGGAGTACCAATTGCCTTATTATGAC ATGGTGCCTTCAGATCCCTCGATAGAGGAAATGAGAAAGGTTGTTTGTGACCAGAAGTTTCGACCAAGTA TCCCAAACCAGTGGCAAAGTTGTGAAGCACTCCGAGTCATGGGGAGAATAATGCGTGAGTGTTGGTATGC CAACGGAGCGGCCCGCCTAACTGCTCTTCGTATTAAGAAGACTATATCTCAACTTTGTGTCAAAGAAGAC TGCAAAGCCTAA >OriGene 5' read for mutant NM_145259 unedited
CCGCCCGTCGAGCAATGGGCGGTAGGCGCTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGA ACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCCATGCTACAG AGTAGTAATCCCTGCTTATCACTGCAAGATATTGCTGGAAATAGTGTAACCCTTGGTTGGGTCCCCAAAT TATTTTTGAAATTTTACTGGTCAGTGAAATTTCCAAATCTGGTAACCACCATTATCAGGACTGAAGTGTG TATGTCTTTTGTGTGATTCTTCAAACTTTACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCT AACCCAATGGGAAAAGAGCAGGTGATCAAATCCTGTTGTCTCCCTTCCAGACTGATGCTTAAGTCCTTCT GTCTATTCCACCATGTTACCAAACCGATGCTGCTCCAAGATTTTGCAACAACATACCCTGCACCTCCACC AGCATCACAAATGCCCAAAACTTGACCCATGGGAGCTGGCAATAATTATAACTTGGCTGTTGCTCCTGTC CTACTGCGATGCTGACGTTTGGCATGCCAGGTCCAATGGTCCCTCGAGGAAAAACCAATTTGAGAACATC TCGAGTCACTTCGGATATCTGAAAATTGAAGTCTGATTGATGTAGCGCTGGTTGGCCTGGCTCTCTTTTC AAGCAATTAGAGACATGCTCTGAATTGAAGGATTTTTGAGTTC >SC323474 kinase domain raw sequence. By performing BLASTX analysis with this sequence against NCBI refernce protein database, you can confirm the presence of the kinase-deficient mutation
TCCCAAACTTGGACCCATGGAGCTGGCCATCATTATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCG ATGCTGACAGTATGGGCATGCCAGGGTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGG AACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGAAAGATCTGATTTATGATGTGACCGC CTCTGGATCTGGCTCTGGTCTACCTCTGTTGGTTCAAAGGACAAT |
| Restriction Sites | Please inquire |
| ACCN | NM_145259 |
| Insert Size | 3500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_145259.1, NP_660302.1 |
| RefSeq Size | 3267 bp |
| RefSeq ORF | 1482 bp |
| Locus ID | 130399 |
| UniProt ID | Q8NER5 |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, Chronic myeloid leukemia, Colorectal cancer, Endocytosis, MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway |
| Gene Summary | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205434 | ACVR1C (Myc-DDK-tagged)-Human activin A receptor, type IC (ACVR1C), transcript variant 1 |
CNY 3,656.00 |
|
| RC205434L1 | Lenti ORF clone of Human activin A receptor, type IC (ACVR1C), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC205434L2 | Lenti ORF clone of Human activin A receptor, type IC (ACVR1C), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC205434L3 | Lenti ORF clone of Human activin A receptor, type IC (ACVR1C), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC205434L4 | Lenti ORF clone of Human activin A receptor, type IC (ACVR1C), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG205434 | ACVR1C (tGFP-tagged) - Human activin A receptor, type IC (ACVR1C), transcript variant 1 |
CNY 4,370.00 |
|
| SC310329 | ACVR1C (untagged)-Human activin A receptor, type IC (ACVR1C), transcript variant 1 |
CNY 3,656.00 |
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