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LAMA3 (NM_001127718) Human Untagged Clone
CAT＃: SC323289
LAMA3 (untagged)-Human laminin, alpha 3 (LAMA3), transcript variant 4
CNY 32,110.00
货期*
7周
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BM600; E170; LAMNA; LOCS |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001127718, the custom clone sequence may differ by one or more nucleotides
ATGCCTCCAGCAGTGAGGCGGTCAGCCTGCAGCATGGGATGGCTGTGGATCTTTGGGGCA GCCCTGGGGCAGTGTCTGGGCTACAGTTCACAGCAGCAAAGGGTGCCATTTCTTCAGCCT CCCGGTCAAAGTCAACTGCAAGCGAGTTATGTGGAGTTTAGACCCAGCCAGGGTTGTAGC CCTGGATACTATCGGGATCATAAAGGCTTGTATACCGGACGGTGTGTTCCCTGCAATTGC AACGGACATTCAAATCAATGCCAGGATGGCTCAGGCATATGTGTTAACTGTCAGCACAAC ACCGCGGGAGAGCACTGTGAACGCTGCCAGGAGGGCTACTATGGCAACGCCGTCCACGGA TCCTGCAGGGCCTGCCCATGTCCTCACACTAACAGCTTTGCCACTGGCTGTGTGGTGAAT GGGGGAGACGTGCGGTGCTCCTGCAAAGCTGGGTACACAGGAACACAGTGTGAAAGGTGT GCACCGGGATATTTCGGGAATCCCCAGAAATTCGGAGGTAGCTGCCAACCATGCAGTTGT AACAGCAATGGCCAGCTGGGCAGCTGTCATCCCCTGACTGGAGACTGCATAAACCAAGAA CCCAAAGATAGCAGCCCTGCAGAAGAATGTGATGATTGCGACAGCTGTGTGATGACCCTC CTGAACGACCTGGCCACCATGGGCGAGCAGCTCCGCCTGGTCAAGTCTCAGCTGCAGGGC CTGAGTGCCAGCGCAGGGCTTCTGGAGCAGATGAGGCACATGGAGACCCAGGCCAAGGAC CTGAGGAATCAGTTGCTCAACTACCGTTCTGCCATTTCAAATCATGGATCAAAAATAGAA GGCCTGGAAAGAGAACTGACTGATTTGAATCAAGAATTTGAGACTTTGCAAGAAAAGGCT CAAGTAAATTCCAGAAAAGCACAAACATTAAACAACAATGTTAATCGGGCAACACAAAGC GCAAAAGAACTGGATGTGAAGATTAAAAATGTCATCCGGAATGTGCACATGCTGAACCGG ATAAGGACCTGGCAGAAAACCCACCAGGGGGAGAACAATGGGCTTGCTAACAGTATCCGG GATTCTTTAAATGAATACGAAGCCAAACTCAGTGACCTTCGTGCTCGGCTGCAGGAGGCA GCTGCCCAAGCCAAGCAGGCAAATGGCTTGAACCAAGAAAACGAGAGAGCTTTGGGAGCC ATTCAGAGACAAGTGAAAGAAATAAATTCCCTGCAGAGTGATTTCACCAAGTATCTAACC ACTGCAGACTCATCTTTGTTGCAAACCAACATTGCGCTGCAGCTGATGGAGAAAAGCCAG AAGGAATATGAAAAATTAGCTGCCAGTTTAAATGAAGCAAGACAAGAACTAAGTGACAAA GTAAGAGAACTTTCCAGATCTGCTGGCAAAACATCCCTTGTGGAGGAGGCAGAAAAGCAC GCGCGGTCCTTACAAGAGCTGGCAAAGCAGCTGGAAGAGATCAAGAGAAACGCCAGCGGG GATGAGCTGGTGCGCTGTGCTGTGGATGCCGCCACCGCCTACGAGAACATCCTCAATGCC ATCAAAGCGGCCGAGGACGCAGCCAACAGGGCTGCCAGTGCATCTGAATCTGCCCTCCAG ACAGTGATAAAGGAAGATCTGCCAAGAAAAGCTAAAACCCTGAGTTCCAACAGTGATAAA CTGTTAAATGAAGCCAAGATGACACAAAAGAAGCTAAAGCAAGAAGTCAGTCCAGCTCTC AACAACCTACAGCAAACCCTGAATATTGTGACAGTTCAGAAAGAAGTGATAGACACCAAT CTCACAACTCTCCGAGATGGTCTTCATGGGATACAGAGAGGTGATATTGATGCTATGATC AGTAGTGCAAAGAGCATGGTCAGAAAGGCCAACGACATCACAGATGAGGTTCTGGATGGG CTCAACCCCATCCAGACAGATGTGGAAAGAATTAAGGACACCTATGGGAGGACACAGAAC GAAGACTTCAAAAAGGCTCTGACTGATGCAGATAACTCGGTGAATAAGTTAACCAACAAA CTACCTGATCTTTGGCGCAAGATTGAAAGTATCAACCAACAGCTGTTGCCCTTGGGAAAC ATCTCTGACAACATGGACAGAATACGAGAACTAATTCAGCAGGCCAGAGATGCTGCCAGT AAGGTTGCTGTCCCCATGAGGTTCAATGGTAAATCTGGAGTCGAAGTCCGACTGCCAAAT GACCTGGAAGATTTGAAAGGATATACATCTCTGTCCTTGTTTCTCCAAAGGCCCAACTCA AGAGAAAATGGGGGTACTGAGAATATGTTTGTGATGTACCTTGGAAATAAAGATGCCTCC CGGGACTACATCGGCATGGCAGTTGTGGATGGCCAGCTCACCTGTGTCTACAACCTGGGG GACCGTGAGGCTGAACTCCAAGTGGACCAGATCTTGACCAAGAGTGAGACTAAGGAGGCA GTTATGGATCGGGTGAAATTTCAGAGAATTTATCAGTTTGCAAGGCTTAATTACACCAAA GGAGCCACATCCAGTAAACCAGAAACACCCGGAGTCTATGACATGGATGGTAGAAATAGC AATACACTCCTTAATTTGGATCCTGAAAATGTTGTATTTTATGTTGGAGGTTACCCACCT GATTTTAAACTTCCCAGTCGACTAAGTTTCCCTCCATACAAAGGTTGTATTGAATTAGAT GACCTCAATGAAAATGTTCTGAGCTTGTACAACTTCAAAAAAACATTCAATCTCAACACA ACTGAAGTGGAGCCTTGTAGAAGGAGGAAGGAAGAGTCAGACAAAAATTATTTTGAAGGT ACGGGCTATGCTCGAGTTCCAACTCAACCACATGCTCCCATCCCAACCTTTGGACAGACA ATTCAGACCACCGTGGATAGAGGCTTGCTGTTCTTTGCAGAAAACGGGGATCGCTTCATA TCTCTAAATATAGAAGATGGCAAGCTCATGGTGAGATACAAACTGAATTCAGAGCTACCA AAAGAGAGAGGAGTTGGAGACGCCATAAACAACGGCAGAGACCATTCGATTCAGATCAAA ATTGGAAAACTCCAAAAGCGTATGTGGATAAATGTGGACGTTCAAAACACTATAATTGAT GGTGAAGTATTTGATTTCAGCACATATTATCTGGGAGGAATTCCAATTGCAATCAGGGAA AGATTTAACATTTCTACGCCTGCTTTCCGAGGCTGCATGAAAAATTTGAAGAAAACCAGT GGTGTCGTTAGATTGAATGATACTGTGGGAGTAACCAAAAAGTGCTCGGAAGACTGGAAG CTTGTGCGATCTGCCTCATTCTCCAGAGGAGGACAATTGAGTTTCACTGATTTGGGCTTA CCACCTACTGACCACCTCCAGGCCTCATTTGGATTTCAGACCTTTCAACCCAGTGGCATA TTATTAGATCATCAGACATGGACAAGGAACCTGCAGGTCACTCTGGAAGATGGTTACATT GAATTGAGCACCAGCGATAGCGGCAGCCCAATTTTTAAATCTCCACAGACGTATATGGAT GGTTTACTGCATTATGTATCTGTAATAAGCGACAACTCTGGACTACGGCTTCTCATCGAT GACCAGCTTCTGAGAAATAGCAAAAGGCTAAAACACATTTCAAGTTCCCGGCAGTCTCTG CGTCTGGGCGGGAGCAATTTTGAGGGTTGTATTAGCAATGTTTTTGTCCAGAGGTTATCA CTGAGTCCTGAAGTCCTAGATTTGACCAGTAACTCTCTCAAGAGAGATGTGTCCCTGGGA GGCTGCAGTTTAAACAAACCACCTTTTCTAATGTTGCTTAAAGGTTCTACCAGGTTTAAC AAGACCAAGACTTTTCGTATCAACCAGCTGTTGCAGGACACACCAGTGGCCTCCCCAAGG AGCGTGAAGGTGTGGCAAGATGCTTGCTCACCACTTCCCAAGACCCAGGCCAATCATGGA GCCCTCCAGTTTGGGGACATTCCCACCAGCCACTTGCTATTCAAGCTTCCTCAGGAGCTG CTGAAACCCAGGTCACAGTTTGCTGTGGACATGCAGACAACATCCTCCAGAGGACTGGTG TTTCACACGGGCACTAAGAACTCCTTTATGGCTCTTTATCTTTCAAAAGGACGTCTGGTC TTTGCACTGGGGACAGATGGGAAAAAATTGAGGATCAAAAGCAAGGAGAAATGCAATGAT GGGAAATGGCACACGGTGGTGTTTGGCCATGATGGGGAAAAGGGGCGCTTGGTTGTGGAT GGACTGAGGGCCCGGGAGGGAAGTTTGCCTGGAAACTCCACCATCAGCATCAGAGCGCCA GTTTACCTGGGATCACCTCCATCAGGGAAACCAAAGAGCCTCCCCACAAACAGCTTTGTG GGATGCCTGAAGAACTTTCAGCTGGATTCAAAACCCTTGTATACCCCTTCTTCAAGCTTC GGGGTGTCTTCCTGCTTGGGTGGTCCTTTGGAGAAAGGCATTTATTTCTCTGAAGAAGGA GGTCATGTCGTCTTGGCTCACTCTGTATTGTTGGGGCCAGAATTTAAGCTTGTTTTCAGC ATCCGCCCAAGAAGTCTCACTGGGATCCTAATACACATCGGAAGTCAGCCCGGGAAGCAC TTATGTGTTTACCTGGAGGCAGGAAAGGTCACGGCCTCTATGGACAGTGGGGCAGGTGGG ACCTCAACGTCGGTCACACCAAAGCAGTCTCTGTGTGATGGACAGTGGCACTCGGTGGCA GTCACCATAAAACAACACATCCTGCACCTGGAACTGGACACAGACAGTAGCTACACAGCT GGACAGATCCCCTTCCCACCTGCCAGCACTCAAGAGCCACTACACCTTGGAGGTGCTCCA GCCAATTTGACGACACTGAGGATCCCTGTGTGGAAATCATTCTTTGGCTGTCTGAGGAAT ATTCATGTCAATCACATCCCTGTCCCTGTCACTGAAGCCTTGGAAGTCCAGGGGCCTGTC AGTCTGAATGGTTGTCCTGACCAG |
| Restriction Sites | Please inquire |
| ACCN | NM_001127718 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001127718.1, NP_001121190.1 |
| RefSeq Size | 5455 bp |
| RefSeq ORF | 5007 bp |
| Locus ID | 3909 |
| UniProt ID | Q16787 |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer |
| Gene Summary | The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014] Transcript Variant: This variant (4) has a distinct 5' UTR, lacks exons in the 5' coding region, lacks an internal in-frame exon, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 4 encode 'a' isoforms. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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