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STING (TMEM173) (NM_198282) Human Untagged Clone
CAT＃: SC321845
TMEM173 (untagged)-Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein
CNY 5,488.00
CNY 7,220.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING-beta; TMEM173 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_198282.1
GCATCCTGGTAACCAGAAGAAAAATATGAGACGGGGAATCATCGTGTGATGTGTGTGCTG
CCTTTGGCTGAGTGTGTGGAGTCCTGCTCAGGTGTTAGGTACAGTGTGTTTGATCGTGGT GGCTTGAGGGGAACCCGCTGTTCAGAGCTGTGACTGCGGCTGCACTCAGAGAAGCTGCCC TTGGCTGCTCGTAGCGCCGGGCCTTCTCTCCTCGTCATCATCCAGAGCAGCCAGTGTCCG GGAGGCAGAAGATGCCCCACTCCAGCCTGCATCCATCCATCCCGTGTCCCAGGGGTCACG GGGCCCAGAAGGCAGCCTTGGTTCTGCTGAGTGCCTGCCTGGTGACCCTTTGGGGGCTAG GAGAGCCACCAGAGCACACTCTCCGGTACCTGGTGCTCCACCTAGCCTCCCTGCAGCTGG GACTGCTGTTAAACGGGGTCTGCAGCCTGGCTGAGGAGCTGCGCCACATCCACTCCAGGT ACCGGGGCAGCTACTGGAGGACTGTGCGGGCCTGCCTGGGCTGCCCCCTCCGCCGTGGGG CCCTGTTGCTGCTGTCCATCTATTTCTACTACTCCCTCCCAAATGCGGTCGGCCCGCCCT TCACTTGGATGCTTGCCCTCCTGGGCCTCTCGCAGGCACTGAACATCCTCCTGGGCCTCA AGGGCCTGGCCCCAGCTGAGATCTCTGCAGTGTGTGAAAAAGGGAATTTCAACGTGGCCC ATGGGCTGGCATGGTCATATTACATCGGATATCTGCGGCTGATCCTGCCAGAGCTCCAGG CCCGGATTCGAACTTACAATCAGCATTACAACAACCTGCTACGGGGTGCAGTGAGCCAGC GGCTGTATATTCTCCTCCCATTGGACTGTGGGGTGCCTGATAACCTGAGTATGGCTGACC CCAACATTCGCTTCCTGGATAAACTGCCCCAGCAGACCGGTGACCATGCTGGCATCAAGG ATCGGGTTTACAGCAACAGCATCTATGAGCTTCTGGAGAACGGGCAGCGGGCGGGCACCT GTGTCCTGGAGTACGCCACCCCCTTGCAGACTTTGTTTGCCATGTCACAATACAGTCAAG CTGGCTTTAGCCGGGAGGATAGGCTTGAGCAGGCCAAACTCTTCTGCCGGACACTTGAGG ACATCCTGGCAGATGCCCCTGAGTCTCAGAACAACTGCCGCCTCATTGCCTACCAGGAAC CTGCAGATGACAGCAGCTTCTCGCTGTCCCAGGAGGTTCTCCGGCACCTGCGGCAGGAGG AAAAGGAAGAGGTTACTGTGGGCAGCTTGAAGACCTCAGCGGTGCCCAGTACCTCCACGA TGTCCCAAGAGCCTGAGCTCCTCATCAGTGGAATGGAAAAGCCCCTCCCTCTCCGCACGG ATTTCTCTTGAGACCCAGGGTCACCAGGCCAGAGCCTCCAGTGGTCTCCAAGCCTCTGGA CTGGGGGCTCTCTTCAGTGGCTGAATGTCCAGCAGAGCTATTTCCTTCCACAGGGGGCCT TGCAGGGAAGGGTCCAGGACTTGACATCTTAAGATGCGTCTTGTCCCCTTGGGCCAGTCA TTTCCCCTCTCTGAGCCTCGGTGTCTTCAACCTGTGAAATGGGATCATAATCACTGCCTT ACCTCCCTCACGGTTGTTGTGAGGACTGAGTGTGTGGAAGTTTTTCATAAACTTTGGATG CTAGTGTAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_198282 |
| Insert Size | 1140 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_198282.1, NP_938023.1 |
| RefSeq Size | 1714 bp |
| RefSeq ORF | 1140 bp |
| Locus ID | 340061 |
| UniProt ID | Q86WV6 |
| Protein Pathways | Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway |
| Gene Summary | This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
,null,
iScience
,PubMed ID 35769880
[STING1]
|
|
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome
,Shum, AK;Deng, Z;Chong, Z;Law, CS;Mukai, K;Ho, FO;,
bioRxiv
[STING1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208418 | TMEM173 (Myc-DDK-tagged)-Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein |
CNY 5,488.00 |
|
| RC208418L1 | Lenti ORF clone of Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC208418L2 | Lenti ORF clone of Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein, mGFP tagged |
CNY 7,888.00 |
|
| RC208418L3 | Lenti ORF clone of Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC208418L4 | Lenti ORF clone of Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein, mGFP tagged |
CNY 7,888.00 |
|
| RG208418 | TMEM173 (tGFP-tagged) - Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein |
CNY 7,088.00 |
