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FGFR3 (NM_000142) Human Untagged Clone
CAT＃: SC310101
FGFR3 (untagged)-Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1
CNY 8,864.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ACH; CD333; CEK2; HSFGFR3EX; JTK4 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_000142 edited
GAATTCGGCACGAGGTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACG GACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTGGGCCCGCGGACAGCGA GCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGG CGCCCGCCTCCCGCCGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTG CCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTC TGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGC GTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTC TTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGG CCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGG CCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGG CAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCC TCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCC CCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAAC ACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAG AACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAG TGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTG GAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCG CACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGAC GTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCAC GTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAG ACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTGCACAACGTCACC TTTGAGGACGCCGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCAC TCTGCGTGGCTGGTGGTGCTGCCAGCCGAGGAGGAGCTGGTGGAGGCTGACGAGGCGGGC AGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTG GCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACC GTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGTGTCCCTGGAGTCCAACGCGTCC ATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACG CTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCC CGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAG GCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTG AAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAG ATGATCGGCAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCC CTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGG CGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACC TTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCC CAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTG ATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAG ACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTC TACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTG GGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGC CACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGC TGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGT GTCCTTACCGTGACGTCCACCGACGAGTACCTGGACCTGTCGGCGCCTTTCGAGCAGTAC TCCCCGGGTGGCCAGGACACCCCCAGCTCCAGCTCCTCAGGGGACGACTCCGTGTTTGCC CACGACCTGCTGCCCCCGGCCCCACCCAGCAGTGGGGGCTCGCGGACGTGAAGGGCCACT GGTCCCCAACAATGTGAGGGGTCCCTAGCAGCCCACCCTGCTGCTGGTGCACAGCCACTC CCCGGCATGAGACTCAGTGCAGATGGAGAGACAGCTACACAGAGCTTTGGTCTGTGTGTG TGTGTGTGCGTGTGTGTGTGTGTGTGCACATCCGCGTGTGCCTGTGTGCGTGCGCATCTT GCCTCCAGGTGCAGAGGTACCCTGGGTGTCCCCGCTGCTGTGCAACGGTCTCCTGACTGG TGCTGCAGCACCGAGGGGCCTTTGTTCTGGGGGGACCCAGTGCAGAATGTAAGTGGGCCC ACCCGGTGGGACCCCCGTGGGGCAGGGAGCTGGGCCCGACATGGCTCCGGCCTCTGCCTT TGCACCACGGGACATCACAGGGTGGGCCTCGGCCCCTCCCACACCCAAAGCTGAGCCTGC AGGGAAGCCCCACATGTCCAGCACCTTGTGCCTGGGGTGTTAGTGGCACCGCCTCCC >Reverse primer walk for NM_000142 unedited
NNNNAACAAAAANNNAANNNNCGAGGAGGGTTGCAGCGGCTGGGCAGCGGAGCGGACGGT GTTGGCGGCCGGCACGGCCAGCAGCTTCTTGTCCATCCGCTCGGGCCGTGTCCAGTAAGG GGCCCCTGTGTCCACACCTGTGTCCTCAGCCTCGTCCTCCCCGTCTTCGTCATCTCCCGA GGATGGAGCGTCTGTCACCCGCACACTGAAGTGGCACAGTACGCGCTGCGTGAGCCGCTG CCGGCAGCTGTAGGCCCCGGAGTCCTCGTGGGAGGCATTCAGCACCTGCAGCCGCTGGGG CCCCACCAGGACACGCTCCGAGGGCACCAGCCCTGTGCCATCCTTGACCCAGACAGTGGG CCCCATGGGACCACCCCCGGGCGGGGGACAGCTCAGCTCCACAGCATCCCCGCTGCCGAA GACCAACTGCTCCTGCTGGCCGGGCTCTGGGCCCGGGACTTCTGCCGCTCGCCCCACGAC GCGCTGCTCCGTCCCCAAGGACTCCGAGGAGGCGCCGGCCACGATGGCCACGGCCACGCA GAGCGCGAGGGCGCAGGCAGGGGCGCCCATGGCGGGGGCGGGGGCCGCGGCGTCCTCAGG CAGCGCGCGCGGGCATGCTGCCCCCCACGGCCCGGCGCGGGCACCGGCGGGAGGCGGGCG CCGCTCGGGAGACTGGCGAGCGCCGGAGCCCGGCTCGCTACGCGCGGCTCCCGCTCCGGC TCGCTGTCCGCGGGCCCAGCTCCCGCCCCGTCCCTCCGGCCGGCGGCCCGCCGGTGCGTC CGTGCGACCGGCAGAGCAGGACCGCGCGGCGCCAGCTGCCCGCGACCTCGTGCCGAATTC GCGGGCGCCCTATAGTGAGTCGTATTACAAAATTCTGACGGTTCACTAAACAAGCTCTGC TTATATAGACCTCCCACCGTACACGCCTACCGCCCATTTGCGTCACCGGGCCGGGGTTAT TACGACATTTTGGAAATCCCGTTGATTTTGGTGCCAAACCAAACTCCCATTGACGTTAAT GGGGGTGGAGACTTGGAAAATCCCCGTGAGATCAAACCCCTATTCCCCCCCCAATTGGTG TACTTGCAAAAACCGCAATCCCCATGGAAAATAGGGAATAACTAAATCGTATAATTGTTC CGCCCAAGTAAGGAAAATTCCCCTAAAGGGCCATGTTCCTGGGGCAATAAAACCCAGGGC GGGGGCACATTTTCCCTCCATTTGTGACTCTCAAAAGGGGGGGGCGGATATTTGTTAAAT >OriGene 3' read for NM_000142 unedited
NNNGGCGAAGCATCAGGGCAGGAAGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGAT CTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTCCAGGTTAGCAACCAGGTGTCTTTATTTTTCGGAAAGTTC GTCGCTGGGTTAACAAAATCGCACCTGCCGGTTTGGGTGACACCTCTGGCCACCATGCAC TGGGCCCCAAAAAAAGACCACCCTGAGCCATGGCCCTGCAGGCAAGCAAGGGACAGCTGC CCAAACTCAGGGCCCAGTAACAGTACAAAACGAACCAACTGAATTCACGGCTTCCCTCCA AGCTTTGAAAGGTAGCAGTCCAGGCTATAAAACTCTAAAAGCATTGCGTAAAAAGTGTTA AGTCTACAACAAATACATCTTGTAAAAACTCAATAAATTATATATATAGATATATATAAA CTTGTAACATCTAATAACATCGGAACCTGCACACAGGGCCGGCCCCTCCCTGGAAACCGT CTCCCTGCCTGGGACACACAGCAATTAGAAAAATTTGTATGAAAATACCAGCTTGCTTTG AAGTCCAAAAAATAAATCTCCTAAAGAAAAATCCTATAGAAATCTAATTCTCCTGAAAAA GGACAAAGGAAATAAAATATCTTCACTGGAATCACCTCCAACTATTAACAACCTTTTAGG CTTGGAGGGGATCCTCCAGCTCCGGGGCAGGCTGGACGTACATTCTTGGCCGTCCCTCTA TCGGCGGGATAAACCTTCTCGGTTGTCAATAAGTTAAAAATTAAAACTCTCCGCCATGTG GCCAGCTAAATGCTGGAAGTGTTGGGGGTGGGGGAACAAAAGTGCCAGGGGCCCATAAAT AGCTTTACAATATACAGGGTCAGTTTTAAAACAAAACTGCGGGGCCAGAAAAAGCCCTGG TCCTCTGCTTGCAAGGGGTGAGACCCCCTGGGGGCCTCCCTCAAGGCCCCCCAAGCCCCG GCCAAGGGCCATGCCTGGCCTCCTGTGCCCCCAGGGGTCGCAAGCCCTCCGTTTGACCAC CCTTTTTCCCCTCCAAAAAGGGTAAAAAAANAAAGGGAAAAAAACCANAAACCCCCCTCT TTTTTAAAGAAAGGGACCCTAATTTTCGGGAAAAACCTTTTGAAAAAAGGGAAAAGGCCC CCCTCTCCGGGACCCCGAATTTCACTCTCTAAGGGCAGGGTGGGGAAAGGGAAACCCGCG GAGGGGGGGAGGGGGGCCCCAAACACCCCCGGGAGT |
| Restriction Sites | Please inquire |
| ACCN | NM_000142 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | There are 2 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of no amino acids. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000142.2, NP_000133.1 |
| RefSeq Size | 4304 bp |
| RefSeq ORF | 2421 bp |
| Locus ID | 2261 |
| UniProt ID | P22607 |
| Domains | pkinase, TyrKc, S_TKc, ig, IGc2, IG |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Bladder cancer, Endocytosis, MAPK signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton |
| Gene Summary | This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1) lacks an alternate coding exon and contains another alternate coding exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis
,Huang, YL;Chou, WC;Hsiung, CN;Hu, LY;Chu, HW;Shen, CY;,
Hum. Mol. Genet.
,PubMed ID 25788520
[FGFR3]
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Resources
Other Versions
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| RC215533L1 | Lenti ORF clone of Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, Myc-DDK-tagged |
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| RC215533L2 | Lenti ORF clone of Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mGFP tagged |
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| RC215533L3 | Lenti ORF clone of Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, Myc-DDK-tagged |
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| RC215533L4 | Lenti ORF clone of Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mGFP tagged |
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| RC600022 | FGFR3 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism), transcript variant 1, Signal peptide (1-22) plus EC domain (23-375) |
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| RG215533 | FGFR3 (tGFP-tagged) - Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1 |
CNY 10,456.00 |
