CASC5 (KNL1) (NM_170589) Human Untagged Clone
CAT＃: SC306673
CASC5 (untagged)-Human cancer susceptibility candidate 5 (CASC5), transcript variant 1
CNY 45220.00
货期*
4周
规格
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Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AF15Q14; CASC5; CT29; D40; hKNL-1; hSpc105; MCPH4; PPP1R55; Spc7 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_170589, the custom clone sequence may differ by one or more nucleotides
ATGGATGGGGTGTCTTCAGAGGCTAATGAAGAAAATGACAATATAGAGAGACCTGTTAGA AGACGGCATTCTTCAATATTGAAACCCCCAAGGAGTCCTCTTCAGGACCTCAGAGGTGGG AATGAAAGAGTTCAGGAATCCAATGCTTTGAGAAATAAGAAAAACTCTCGTCGAGTCAGC TTTGCAGATACTATAAAGGTATTCCAGACGGAGTCTCATATGAAAATAGTGAGAAAGTCA GAAATGGAAGGCTGCAGTGCAATGGTGCCATCTCAGCTGCAACTTCTGCCTCCTGGGTTT AAGCGATTCTCCTGCCTCAGCCTCCCAGAAACAGAAACAGGAGAAAATCTTCTTTTGATA CAGAATAAGAAATTAGAAGATAATTACTGTGAAATTACTGGGATGAACACATTGCTTTCT GCTCCCATTCATACCCAGATGCAACAGAAGGAGTTTTCAATTATAGAACATACCCGTGAA AGGAAACATGCAAATGACCAGACAGTCATTTTTTCAGATGAAAACCAGATGGACCTGACA TCAAGTCACACTGTAATGATTACCAAAGGCCTTTTAGATAATCCCATAAGTGAAAAGTCC ACCAAGATAGATACCACATCATTTCTAGCTAATTTAAAGCTTCACACCGAGGACTCAAGA ATGAAAAAAGAAGTAAATTTTTCCGTGGATCAAAACACTTCTTCAGAAAATAAAATAGAT TTCAATGACTTCATAAAAAGATTGAAAACAGGAAAATGTAGTGCTTTTCCTGATGTGCCT GATAAAGAAAATTTTGAGATACCTATTTATTCCAAGGAACCGAACAGTGCCTCTTCTACA CATCAAATGCATGTATCTCTTAAGGAAGATGAAAATAACAGTAATATTACTAGGCTCTTT AGAGAAAAAGATGATGGGATGAATTTCACCCAGTGTCATACAGCCAATATTCAGACATTG ATTCCCACATCCAGTGAGACCAACTCACGGGAATCTAAAGGTAATGATATTACAATTTAT GGCAATGACTTTATGGACTTGACATTTAACCACACTTTGCAGATCTTACCTGCAACAGGT AATTTTTCTGAAATAGAAAATCAAACTCAGAATGCCATGGATGTAACAACAGGTTATGGA ACTAAAGCTTCAGGAAATAAAACAGTTTTTAAGAGTAAACAAAATACTGCTTTTCAAGAC CTTTCCATAAACTCTGCAGACAAAATACATATTACCAGAAGTCATATTATGGGGGCAGAA ACTCACATAGTCTCACAGACTTGTAATCAGGATGCCAGAATATTAGCCATGACCCCAGAA TCTATATATTCTAATCCATCTATTCAAGGTTGTAAGACTGTTTTCTATTCTAGTTGTAAT GATGCCATGGAAATGACCAAATGTCTCTCAAATATGAGAGAGGAGAAAAATTTGCTAAAG CATGACAGTAATTATGCTAAAATGTATTGCAATCCAGATGCTATGTCTTCTCTCACAGAG AAAACTATTTATTCCGGAGAGGAGAACATGGACATTACCAAGAGTCATACAGTTGCAATA GATAATCAAATTTTTAAACAAGATCAATCAAATGTGCAAATAGCAGCTGCACCAACACCC GAAAAAGAAATGATGCTCCAAAATCTTATGACCACATCAGAAGATGGGAAAATGAATGTA AATTGTAACTCAGTTCCTCATGTATCTAAGGAAAGAATACAGCAGAGCCTGTCAAATCCT TTGTCTATTTCATTGACTGATAGAAAGACTGAACTCTTATCAGGTGAAAATATGGATTTG ACTGAAAGTCACACAAGTAACTTAGGAAGTCAGGTTCCTCTTGCAGCTTATAATCTAGCA CCGGAGAGTACCAGTGAATCTCACTCTCAGAGCAAAAGCTCTTCAGATGAATGTGAAGAA ATTACCAAAAGTCGTAATGAACCATTTCAGCGATCAGACATAATAGCCAAAAACAGCTTA ACCGACACCTGGAACAAAGACAAAGATTGGGTTTTGAAGATTTTGCCCTACCTTGATAAA GATTCTCCTCAGTCAGCTGATTGTAATCAGGAGATAGCAACAAGCCATAATATAGTCTAC TGTGGTGGAGTTCTTGATAAACAAATAACTAATAGAAATACAGTATCATGGGAACAATCT TTGTTTTCTACCACAAAGCCATTATTTTCATCAGGACAGTTCTCTATGAAAAATCATGAT ACTGCTATAAGTAGTCATACAGTGAAATCTGTACTAGGCCAGAATTCTAAACTGGCTGAG CCACTGAGGAAAAGTTTAAGCAATCCCACACCTGACTATTGCCATGACAAGATGATTATA TGTTCAGAGGAAGAGCAAAATATGGATCTAACAAAGAGCCACACTGTCGTCATTGGATTT GGTCCTTCTGAACTACAAGAACTTGGTAAAACTAATTTAGAACACACTACTGGCCAGCTA ACAACAATGAACAGACAGATAGCTGTAAAAGTTGAAAAATGTGGTAAAAGTCCCATAGAA AAAAGTGGAGTGCTTAAATCTAACTGTATTATGGATGTGTTAGAGGACGAAAGTGTACAG AAACCTAAATTTCCAAAGGAAAAGCAAAATGTCAAAATTTGGGGAAGGAAAAGTGTTGGT GGACCAAAAATTGATAAGACTATTGTATTTTCAGAAGACGATAAGAATGATATGGATATC ACTAAGAGTTATACAATAGAAATAAACCATAGACCTTTATTAGAGAAACGTGATTGTCAT TTGGTGCCATTGGCAGGAACTTCTGAAACTATTTTATATACATGTGGGCAGGATGACATG GAGATCACTAGAAGTCACACAACTGCCTTAGAATGTAAAACTGTCTCACCAGATGAAATA ACTACTAGGCCTATGGACAAAACTGTAGTGTTTGTAGATAATCATGTTGAACTAGAAATG ACAGAGTCCCATACTGTTTTCATTGACTACCAAGAAAAGGAAAGAACAGACAGACCTAAC TTTGAACTATCCCAAAGGAAAAGCCTAGGAACACCAACAGTGATATGTACTCCTACTGAG GAGAGTGTTTTCTTTCCAGGAAATGGTGAAAGTGACCGTCTAGTAGCAAATGACAGCCAG CTAACCCCTCTGGAGGAATGGTCTAATAATAGGGGCCCTGTAGAGGTAGCTGATAACATG GAATTGTCTAAATCAGCCACTTGCAAAAACATCAAAGATGTACAAAGTCCTGGATTTCTG AATGAACCTCTATCAAGCAAAAGTCAGAGAAGAAAAAGCCTTAAGCTAAAAAATGACAAG ACCATTGTATTTTCAGAGAATCATAAAAATGATATGGATATTACCCAGAGTTGTATGGTG GAAATAGATAACGAAAGTGCCCTGGAGGATAAAGAGGACTTCCATTTGGCAGGGGCTTCT AAAACTATTTTGTATTCATGTGGGCAGGATGACATGGAGATCACTAGGAGTCACACAACT GCCTTAGAATGTAAAACTCTCCTGCCAAATGAAATAGCTATTAGGCCCATGGACAAAACC GTATTGTTCACAGATAATTACAGTGATCTGGAAGTCACCGATTCCCATACTGTTTTCATT GACTGTCAAGCCACAGAGAAAATACTTGAAGAAAACCCTAAATTTGGAATAGGAAAAGGA AAAAACTTGGGTGTTTCCTTTCCTAAGGATAATAGCTGTGTTCAAGAAATCGCTGAAAAA CAAGCACTGGCTGTAGGAAACAAAATAGTTCTTCACACCGAGCAAAAGCAACAACTCTTT GCTGCTACTAATAGAACTACTAATGAAATCATCAAATTTCATAGTGCTGCTATGGATGAA AAGGTCATAGGGAAAGTTGTAGACCAGGCCTGTACATTGGAAAAAGCGCAAGTTGAAAGC TGTCAGTTAAATAATAGAGATAGAAGAAATGTGGACTTTACAAGTAGTCATGCAACTGCT GTTTGTGGATCCAGTGATAATTATTCCTGTTTACCAAATGTTATTTCCTGTACTGATAAT TTGGAGGGTAGTGCCATGCTCTTATGTGATAAAGATGAGGAAAAAGCCAATTATTGCCCA GTGCAAAATGATCTTGCTTATGCAAATGATTTTGCCAGTGAATATTACTTGGAATCTGAG GGACAGCCTCTCTCTGCTCCTTGTCCTTTGTTAGAGAAGGAAGAAGTTATTCAAACCAGT ACCAAAGGACAGTTAGACTGTGTTATAACACTGCACAAAGATCAAGATCTGATTAAGGAT CCACGAAATCTATTGGCTAATCAAACTTTAGTATATAGTCAAGATCTGGGGGAGATGACT AAACTTAATTCAAAGCGAGTATCTTTTAAGCTTCCAAAGGATCAAATGAAAGTCTATGTT GATGACATTTATGTTATTCCTCAGCCTCATTTCTCAACCGACCAACCTCCATTACCTAAA AAAGGACAGAGTAGTATCAATAAAGAAGAAGTAATACTGTCTAAAGCTGGAAATAAGAGT TTAAATATTATAGAAAATTCCTCTGCACCCATATGTGAAAACAAGCCCAAAATACTCAAT AGTGAGGAATGGTTTGCTGCAGCCTGTAAAAAAGAACTGAAGGAAAATATTCAAACAACT AACTATAATACAGCTCTAGATTTCCACAGTAACTCAGACGTAACTAAGCAAGTCATTCAA ACTCATGTCAATGCTGGAGAAGCACCAGATCCTGTAATTACATCTAATGTTCCATGTTTT CATAGTATCAAACCAAATCTGAATAATTTGAATGGAAAAACTGGAGAGTTTTTAGCCTTT CAAACTGTTCATCTACCACCCCTTCCAGAGCAATTACTTGAATTAGGAAATAAGGCACAC AATGATATGCATATAGTGCAAGCTACAGAAATACATAATATTAACATAATCTCCAGCAAT GCTAAAGATAGTAGAGATGAGGAAAATAAAAAGTCTCATAATGGAGCTGAAACCACCTCT CTACCGCCAAAGACAGTTTTTAAAGATAAAGTAAGGAGATGTTCTTTGGGAATCTTTTTG CCTAGATTGCCCAACAAGAGAAATTGTAGTGTCACTGGTATTGATGACCTGGAACAGATT CCAGCAGACACAACTGATATAAATCACTTAGAAACTCAGCCGGTCTCTAGCAAAGATTCA GGCATTGGATCTGTTGCAGGTAAACTGAACCTAAGTCCTTCTCAATATATAAATGAGGAA AATCTTCCTGTATATCCTGATGAGATCAATTCTTCAGACTCTATTAACATAGAAACTGAG GAAAAGGCCTTGATTGAGACATACCAAAAAGAGATTTCACCATATGAAAATAAAATGGGA AAAACTTGCAATAGCCAAAAAAGAACGTGGGTACAAGAAGAAGAAGATATTCATAAGGAG AAAAAAATCAGAAAAAATGAGATTAAGTTTAGTGATACGACACAAGATCGGGAGATTTTT GATCACCATACTGAAGAGGATATAGATAAAAGTGCTAACAGTGTATTGATAAAAAACCTG AGCAGGACCCCATCTAGTTGCAGCAGCTCTCTGGATTCAATCAAGGCTGATGGGACCTCT CTGGACTTCAGCACTTACCGCAGTAGTCAAATGGAATCACAGTTTCTCAGAGATACTATT TGTGAAGAGAGCTTGAGGGAGAAACTCCAAGATGGGAGAATAACAATAAGGGAGTTCTTT ATACTTCTCCAGGTCCACATCTTGATACAGAAACCCCGACAGAGCAATCTCCCAGGCAAT TTTACTGTAAACACACCACCTACTCCAGAAGACCTGATGTTAAGTCAATATGTTTACCGA CCCAAGATACAGATTTATAGAGAAGATTGTGAGGCTCGTCGCCAAAAGATTGAAGAATTA AAGCTTTCTGCATCGAACCAAGATAAGCTGTTGGTTGATATAAATAAGAACCTGTGGGAA AAAATGAGACACTGCTCTGACAAAGAGCTGAAGGCCTTTGGAATTTATCTTAACAAAATA AAGTCATGTTTTACCAAGATGACTAAAGTCTTCACTCACCAAGGAAAAGTGGCTCTGTAT GGCAAGCTGGTGCAGTCAGCTCAGAATGAGAGGGAGAAACTTCAAATAAAGATAGATGAG ATGGATAAAATACTTAAGAAGATCGATAACTGCCTCACTGAGATGGAAACAGAAACTAAG AATTTGGAGGATGAAGAGAAAAACAATCCTGTGGAAGAATGGGATTCTGAAATGAGAGCT GCAGAAAAAGAATTGGAACAGCTGAAAACTGAAGAAGAGGAGCTTCAAAGAAATCTCTTA GAACTGGAGGTACAAAAAGAGCAGACCCTTGCTCAAATAGACTTTATGCAAAAACAAAGA AATAGAACTGAAGAGCTACTGGATCAGTTGAGCTTGTCTGAGTGGGATGTCGTTGAGTGG AGTGATGATCAAGCTGTATTCACCTTTGTTTATGACACGATACAACTCACCATCACCTTT GAAGAGTCAGTTGTTGGTTTCCCTTTCCTGGACAAGCGTTATAGGAAGATTGTTGATGTC AATTTTCAATCTCTGTTAGATGAGGATCAAGCTCCTCCTTCCTCCCTTTTAGTTCATAAG CTTATTTTCCAGTACGTTGAAGAAAAGGAATCCTGGAAGAAGACATGTACAACCCAGCAT CAGTTACCCAAGATGCTTGAAGAATTCTCACTGGTAGTGCACCATTGCAGACTCCTTGGA GAGGAGATTGAGTATTTAAAGAGATGGGGACCAAATTATAACCTAATGAACATAGATATT AATAATAATGAATTGAGACTTTTATTCTCTAGCTCCGCAGCATTTGCAAAGTTTGAAATA ACTTTGTTTCTCTCAGCCTATTATCCATCTGTACCATTACCTTCCACCATTCAGAATCAC GTTGGGAACACTAGCCAAGATGATATTGCTACCATTCTATCTAAAGTGCCACTGGAGAAC AACTACCTGAAGAATGTAGTCAAGCAAATTTACCAAGATCTGTTTCAGGACTGCCATTTC TACCACTAG |
| Restriction Sites | Please inquire |
| ACCN | NM_170589 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_170589.2, NP_733468.2 |
| RefSeq Size | 8708 bp |
| RefSeq ORF | 7029 bp |
| Locus ID | 57082 |
| UniProt ID | Q8NG31 |
| Gene Summary | The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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