Desmocollin 1 (DSC1) (NM_004948) Human Untagged Clone
CAT＃: SC303554
DSC1 (untagged)-Human desmocollin 1 (DSC1), transcript variant Dsc1b
CNY 16250.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDHF1; DG2/DG3 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_004948, the custom clone sequence may differ by one or more nucleotides
ATGGCTCTGGCCTCTGCTGCCCCAGGGAGCATCTTCTGTAAGCAGCTCCTTTTCTCTCTC CTGGTTTTAACATTACTTTGCGATGCTTGTCAGAAAGTTTATCTTCGAGTTCCTTCTCAT CTTCAGGCTGAAACACTTGTAGGCAAAGTGAATCTGGAGGAGTGTCTCAAGTCGGCCAGC CTAATCCGGTCCAGTGACCCTGCCTTCAGAATTCTAGAAGATGGCTCAATTTACACAACA CATGACCTCATTTTGTCTTCTGAAAGGAAAAGTTTTTCCATTTTCCTTTCAGATGGTCAG AGACGGGAACAACAAGAGATAAAAGTTGTACTGTCAGCAAGAGAAAACAAGTCTCCTAAG AAGAGACATACCAAAGACACAGCCCTCAAGCGCAGCAAGAGACGATGGGCTCCTATTCCA GCTTCATTGATGGAGAACTCGTTGGGTCCATTTCCACAACACGTTCAGCAGATCCAATCT GATGCTGCACAGAATTACACCATCTTTTATTCCATAAGTGGGCCAGGCGTGGACAAAGAA CCCTTCAATTTGTTTTACATAGAGAAAGACACTGGGGATATCTTTTGTACAAGGAGCATT GACCGTGAGAAATATGAACAGTTTGCGTTATATGGCTATGCAACAACTGCAGATGGCTAT GCACCAGAATATCCACTCCCTTTGATCATCAAAATTGAAGATGATAATGATAACGCCCCA TATTTTGAACACAGAGTGACTATCTTTACTGTGCCTGAAAATTGCCGATCCGGAACTTCA GTGGGAAAAGTGACCGCCACAGACCTTGACGAACCTGACACTCTCCATACTCGTCTGAAA TATAAAATCTTACAACAAATCCCAGATCATCCAAAGCATTTCTCCATACACCCAGATACC GGTGTCATCACCACAACTACACCTTTTCTGGATAGAGAAAAATGTGATACTTACCAGTTA ATAATGGAAGTGCGAGACATGGGTGGTCAGCCTTTCGGTTTATTTAATACAGGAACAATT ACTATTTCACTTGAGGATGAAAATGACAATCCACCATCTTTCACAGAAACTTCTTATGTT ACAGAAGTAGAAGAAAACAGAATTGACGTGGAGATTTTACGAATGAAGGTACAGGATCAG GATTTGCCAAACACTCCTCACTCAAAGGCTGTATACAAAATCCTACAAGGAAATGAAAAT GGAAACTTCATAATTAGCACAGATCCAAATACAAATGAAGGAGTGCTGTGTGTTGTCAAG CCATTGAACTATGAAGTCAATCGCCAAGTTATTTTGCAAGTTGGTGTCATTAACGAGGCA CAATTCTCTAAAGCAGCGAGCTCACAAACTCCTACAATGTGCACTACAACTGTCACCGTT AAAATTATAGACAGTGATGAGGGCCCTGAATGCCACCCTCCAGTGAAAGTTATTCAGAGT CAAGATGGCTTCCCAGCTGGCCAAGAACTCCTTGGATACAAAGCACTGGACCCGGAAATA TCCAGTGGTGAAGGCTTAAGGTATCAGAAGTTAGGGGATGAAGATAACTGGTTTGAAATT AATCAACACACTGGCGACTTGAGAACTCTAAAAGTACTAGATAGAGAATCCAAATTTGTA AAAAACAACCAATACAATATTTCAGTTGTTGCAGTGGATGCAGTTGGCCGATCTTGCACT GGAACATTAGTAGTTCATTTGGATGATTACAACGATCACGCACCTCAAATTGACAAAGAA GTGACCATTTGTCAGAATAATGAGGATTTTGCTGTTCTGAAACCTGTAGATCCAGATGGA CCTGAAAATGGACCACCTTTTCAATTCTTTCTGGATAATTCTGCCAGTAAAAACTGGAAC ATAGAAGAAAAGGATGGTAAAACTGCCATTCTTCGTCAACGGCAAAATCTTGATTATAAC TATTATTCTGTGCCTATTCAAATAAAAGACAGGCATGGTTTAGTTGCAACACATATGTTA ACAGTGAGAGTATGTGACTGTTCAACTCCATCTGAGTGTAGAATGAAGGATAAAAGTACA AGAGACGTTAGACCAAATGTAATACTTGGAAGATGGGCTATTCTTGCTATGGTGTTGGGT TCTGTATTGTTATTATGTATTCTGTTTACATGTTTCTGTGTCACTGCTAAGAGAACAGTC AAGAAATGTTTTCCAGAAGACATAGCCCAGCAAAATTTAATTGTATCAAATACTGAAGGA CCTGGAGAAGAAGTAACGGAAGCAAATATTAGACTCCCCATGCAGACATCCAACATTTGT GACACAAGCATGTCTGTTGGTACTGTTGGTGGCCAGGGAATCAAAACACAGCAAAGTTTT GAGATGGTCAAAGGAGGCTACACTTTGGATTCCAACAAAGGAGGTGGACATCAGACCTTG GAGTCCGTCAAGGGAGTGGGGCAGGGAGATACTGGCAGATATGCGTACACGGACTGGCAG AGTTTCACCCAACCTCGGCTTGGCGAAGAATCCATTAGAGGACACACTCTGATTAAAAAT TAA |
| Restriction Sites | Please inquire |
| ACCN | NM_004948 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004948.2, NP_004939.1 |
| RefSeq Size | 4271 bp |
| RefSeq ORF | 2523 bp |
| Locus ID | 1823 |
| UniProt ID | Q08554 |
| Domains | CA |
| Protein Families | Transmembrane |
| Gene Summary | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015] Transcript Variant: This variant (Dsc1b) includes an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to isoform Dsc1a. The encoded isoform (Dsc1b) is shorter than isoform Dsc1a. This isoform (Dsc1b) may undergo proteolytic processing similar to isoform Dsc1a. |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220415 | DSC1 (Myc-DDK-tagged)-Human desmocollin 1 (DSC1), transcript variant Dsc1b |
CNY 7130.00 |
|
| RC220415L3 | Lenti-ORF clone of DSC1 (Myc-DDK-tagged)-Human desmocollin 1 (DSC1), transcript variant Dsc1b |
CNY 9030.00 |
|
| RC220415L4 | Lenti-ORF clone of DSC1 (mGFP-tagged)-Human desmocollin 1 (DSC1), transcript variant Dsc1b |
CNY 9030.00 |
|
| RG220415 | DSC1 (tGFP-tagged) - Human desmocollin 1 (DSC1), transcript variant Dsc1b |
CNY 7890.00 |
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