Exonuclease 1 (EXO1) (NM_006027) Human Untagged Clone
CAT＃: SC124403
EXO1 (untagged)-Human exonuclease 1 (EXO1), transcript variant 1
CNY 6208.00
| Cited in 2 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HEX1; hExoI |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124403 sequence for NM_006027 edited (data generated by NextGen Sequencing)
ATGGGGATACAGGGATTGCTACAATTTATCAAAGAAGCTTCAGAACCCATCCATGTGAGG AAGTATAAAGGGCAGGTAGTAGCTGTGGATACATATTGCTGGCTTCACAAAGGAGCTATT GCTTGTGCTGAAAAACTAGCCAAAGGTGAACCTACTGATAGGTATGTAGGATTTTGTATG AAATTTGTAAATATGTTACTATCTCATGGGATCAAGCCTATTCTCGTATTTGATGGATGT ACTTTACCTTCTAAAAAGGAAGTAGAGAGATCTAGAAGAGAAAGACGACAAGCCAATCTT CTTAAGGGAAAGCAACTTCTTCGTGAGGGGAAAGTCTCGGAAGCTCGAGAGTGTTTCACC CGGTCTATCAATATCACACATGCCATGGCCCACAAAGTAATTAAAGCTGCCCGGTCTCAG GGGGTAGATTGCCTCGTGGCTCCCTATGAAGCTGATGCGCAGTTGGCCTATCTTAACAAA GCGGGAATTGTGCAAGCCATAATTACAGAGGACTCGGATCTCCTAGCTTTTGGCTGTAAA AAGGTAATTTTAAAGATGGACCAGTTTGGAAATGGACTTGAAATTGATCAAGCTCGGCTA GGAATGTGCAGACAGCTTGGGGATGTATTCACGGAAGAGAAGTTTCGTTACATGTGTATT CTTTCAGGTTGTGACTACCTGTCATCACTGCGTGGGATTGGATTAGCAAAGGCATGCAAA GTCCTAAGACTAGCCAATAATCCAGATATAGTAAAGGTTATCAAGAAAATTGGACATTAT CTCAAGATGAATATCACGGTACCAGAGGATTACATCAACGGGTTTATTCGGGCCAACAAT ACCTTCCTCTATCAGCTAGTTTTTGATCCCATCAAAAGGAAACTTATTCCTCTGAACGCC TATGAAGATGATGTTGATCCTGAAACACTAAGCTACGCTGGGCAATATGTTGATGATTCC ATAGCTCTTCAAATAGCACTTGGAAATAAAGATATAAATACTTTTGAACAGATCGATGAC TACAATCCAGACACTGCTATGCCTGCCCATTCAAGAAGTCATAGTTGGGATGACAAAACA TGTCAAAAGTCAGCTAATGTTAGCAGCATTTGGCATAGGAATTACTCTCCCAGACCAGAG TCGGGTACTGTTTCAGATGCCCCACAATTGAAGGAAAATCCAAGTACTGTGGGAGTGGAA CGAGTGATTAGTACTAAAGGGTTAAATCTCCCAAGGAAATCATCCATTGTGAAAAGACCA AGAAGTGCAGAGCTGTCAGAAGATGACCTGTTGAGTCAGTATTCTCTTTCATTTACGAAG AAGACCAAGAAAAATAGCTCTGAAGGCAATAAATCATTGAGCTTTTCTGAAGTGTTTGTG CCTGACCTGGTAAATGGACCTACTAACAAAAAGAGTGTAAGCACTCCACCTAGGACGAGA AATAAATTTGCAACATTTTTACAAAGGAAAAATGAAGAAAGTGGTGCAGTTGTGGTTCCA GGGACCAGAAGCAGGTTTTTTTGCAGTTCAGATTCTACTGACTGTGTATCAAACAAAGTG AGCATCCAGCCTCTGGATGAAACTGCTGTCACAGATAAAGAGAACAATCTGCATGAATCA GAGTATGGAGACCAAGAAGGCAAGAGACTGGTTGACACAGATGTAGCACGTAATTCAAGT GATGACATTCCGAATAATCATATTCCAGGTGATCATATTCCAGACAAGGCAACAGTGTTT ACAGATGAAGAGTCCTACTCTTTTGAGAGCAGCAAATTTACAAGGACCATTTCACCACCC ACTTTGGGAACACTAAGAAGTTGTTTTAGTTGGTCTGGAGGTCTTGGAGATTTTTCAAGA ACGCCGAGCCCCTCTCCAAGCACAGCATTGCAGCAGTTCCGAAGAAAGAGCGATTCCCCC ACCTCTTTGCCTGAGAATAATATGTCTGATGTGTCGCAGTTAAAGAGCGAGGAGTCCAGT GACGATGAGTCTCATCCCTTACGAGAAGAGGCATGTTCTTCACAGTCCCAGGAAAGTGGA GAATTCTCACTGCAGAGTTCAAATGCATCAAAGCTTTCTCAGTGCTCTAGTAAGGACTCT GATTCAGAGGAATCTGATTGCAATATTAAGTTACTTGACAGTCAAAGTGACCAGACCTCC AAGCTATGTTTATCTCATTTCTCAAAAAAAGACACACCTCTAAGGAACAAGGTTCCTGGG CTATATAAGTCCAGTTCTGCAGACTCTCTTTCTACAACCAAGATCAAACCTCTAGGACCT GCCAGAGCCAGTGGGCTGAGCAAGAAGCCGGCAAGCATCCAGAAGAGAAAGCATCATAAT GCCGAGAACAAGCCGGGGTTACAGATCAAACTCAATGAGCTCTGGAAAAACTTTGGATTT AAAAAAGATTCTGAAAAGCTTCCTCCTTGTAAGAAACCCCTGTCCCCAGTCAGAGATAAC ATCCAACTAACTCCAGAAGCGGAAGAGGATATATTTAACAAACCTGAATGTGGCCGTGTT CAAAGAGCAATATTCCAGTAA Clone variation with respect to NM_006027.4 2167 c=>t >OriGene 5' read for NM_006027 unedited
CGGCAACATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGAAGCAAGTTA CCCGTGTTCTGCGTTGCCGGCCGTGGGTGCTCTGGCCACAGTGAGTTAGGGGCGTCGGAG CGGGTTTCTCCAACCGCAATCGGCTCCGCTCAAGGGGAGGAGGAGAGTCCCTTCTCGGAA GGCCTAAGGAAACGTGTCGTCTGGAATGGGCTTGGGGGCCACGCCTGCACATCTCCGCGA GACAGAGGGATAAAGTGAAGATGGTGCTGTTATTGTTACCTCGAGTGCCACATGCGACCT CTGAGATATGTACACAGTCATTCTTACTATCGCACTCAGCCATTCTTACTACGCTAAAGA AGAAATAATTATTCGAGGATATTTGCCTGGCCCAGAAGAAACTTATGTAAATTTCATGAA CTATTATATCCGTTTTCCTCGGAGTGAGAGAAAACTCTTTTTAGATATCATCTGAGAGCA GAACTAGTGAATCCCAGTCACTGAGTGGAGTTGAGAGTCTAAGAACCTCTGAAATTTGAG AACTGCTGGACCAGAGCCTTTAGAGCTCTGATAAGGTGTCAACAGGGTAGTTAATTTGGC ACCATGGGGATACAGGGATTGCTACAATTTATCAAAGAAGCTTCAGAACCCATCCATGTG ANGAAGTATAAAGGGCANGTAGTAGCTGTGGATACATATTGCTGGCTTCACAAAGGAGCT ATTGCTTGTGCTGAANAACTAGCCAAAGGTGAACCTACTGATAGGTATGTAGGAATTTGT ATGAAATTTGTAATATNGTACTATCTCATGGGATCAAGCCTATTCTCGTATTTGATGGAT GTACTTTACCTTCTAAAAAGGAGTNNAGAGATCTANAAGAGAAGACGACAGCCAATCTTC TAAGGGAAANGCACNTNCTNCGGAAG >OriGene 3' read for NM_006027 unedited
GGTATATCTATGNNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAGGCAAAATACAAAATGTTTTCTAT TTTTAAAATGGCCCAAAATGAAAAAAAATTCTTCATGCTGATAAGTGCCCCATTCCCAAA CAGGGACTTCAAATTGATCAAATTCTCTTGCAGGCAAAAGCTTTGCAGCAGTCTGCATTT ACTGGAATATTGCTCTTTGAACACGGCCACATTCAGGTTTGTTAAATATATCCCCTTCCG CTTCTGGAGTTAGTTGGATGTTATCTCTGACTGGGGACAGGGGTTTCTTACAAGGAGGAA GCTTTTCAAAATCTTTTTTAAATCCAAAGTTTTTCCAGAGCTCATTGAGTTTGATCTGTA ACCCCGGCTTGGTCTCGGCATTATGATGCTTTCTCTTCTGGATGCTTGCCGGCTTCTTGC TCAACCCACTGGCTCTGGCAGGTCCTAAAGGTTTGATCTTGGTTGTAGAAAGAGAGTCTG CANAACTGGACTTATATAGCCCAAGAACCTTGTTCCTTAGAGGTGTGTCTTTTTTTTGAA AATGGAGAAAACATAGCTTGAGGTCTGGGCACTTTGCTGGAAGTAACTTAATATGCAATC AGATTCCTCTGAATCAAATCCCTTACTAAACACTGGGAAAACTTTGATGCCTTTGAACTC TGCGGGAGAAATCCCCCCTTTTCCGGGACGGGAAAAACAAGCCCCTCCTCTAGGGGGAGA AACTACACCGCCCTGGGGCTCCCCCTCCTTAACTGGGAAACCTTCAAAATATTTTTCCTC CGGCAAAAAGGGGGGGAAATCCTCCTTTCTCCGAAAGGGCGCAAGCTGTGCTGGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006027 |
| Insert Size | 3300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_006027.3, NP_006018.3 |
| RefSeq Size | 3140 bp |
| RefSeq ORF | 2541 bp |
| Locus ID | 9156 |
| UniProt ID | Q9UQ84 |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Mismatch repair |
| Gene Summary | This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longest isoform (b). Both variants 1 and 2 encode isoform b. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Involvement of Exo1b in DNA damage-induced apoptosis
,Emma Bolderson, Derek J. Richard, Winfried Edelmann, and Kum Kum Khanna,
Nucleic Acids Res., Jun 2009; 37: 3452 - 3463.
[EXO1]
|
|
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
,Emma Bolderson, Nozomi Tomimatsu, Derek J. Richard, Didier Boucher, Rakesh Kumar, Tej K. Pandita, Sandeep Burma, and Kum Kum Khanna,
Nucleic Acids Res., Apr 2010; 38: 1821 - 1831
[EXO1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC214294 | EXO1 (Myc-DDK-tagged)-Human exonuclease 1 (EXO1), transcript variant 1 |
CNY 6200.00 |
|
| RC214294L3 | Lenti ORF clone of Human exonuclease 1 (EXO1), transcript variant 1, Myc-DDK-tagged |
CNY 8600.00 |
|
| RC214294L4 | Lenti ORF clone of Human exonuclease 1 (EXO1), transcript variant 1, mGFP tagged |
CNY 5890.00 |
|
| RG214294 | EXO1 (tGFP-tagged) - Human exonuclease 1 (EXO1), transcript variant 1 |
CNY 4370.00 |
其它Exonuclease 1产品
