RAB7B (BC007382) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	RAB7
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC007382 edited GGCACGAGGCTTTTTCTTCTGGCTCCAGGCAGCACAGACAGGGCCTAGCCTGGAGAGGGT GGACAAGATGTCCTCTCAGGGTCTTCAATGGCCAAGTCCAAGCCCACTGCAGAATCTTTC TGTCTACCCGTAAGTATCCTTTCCTGAGTTCCAGGCAAAGCTGGGGATGTTAGCCTATGA CTGTCATCTGACTTGGAAGGTACACCTAGGGGCCGGGGGGAGGTCAGCAGGGGAGTTTGG GAGCCACTTCTCCCCCCACGTGGCACTGGAGTGTGAACTGGCTCATTCTGGACACCAGCA TGGAGCCAGCACGGGAACAGGGGGGCAGCCTAGAGCACAAGCTCTATCTGTGTCCTTCAG AGCTCCTGGGAAACATGATGCGCCCTCATGGGAATGGCATTTTGCATATCACACAGGCTG TCCTGGGAGTCAGGCAGACTGGATTGTCACGTGCGGTGTGCATGCAGCAGCTTGTGCACT GCAGTGGACCTGTGGACCATTTCTAAAGGTGCACAACAAATAATAAATGTGTCCTTCTTT GTTTTTTAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC007382 unedited TACGACTACTATAGGGCGGCCGCGAATTCGGCACGAGGCTTTTTCTTCTGGCTCCAGGCA GCACAGACAGGGCCTAGCCTGGAGAGGGTGGACAAGATGTCCTCTCAGGGTCTTCAATGG CCAAGTCCAAGCCCACTGCAGAATCTTTCTGTCTACCCGTAAGTATCCTTTCCTGAGTTC CAGGCAAAGCTGGGGATGTTAGCCTATGACTGTCATCTGACTTGGAAGGTACACCTAGGG GCCGGGGGGAGGTCAGCAGGGGAGTTTGGGAGCCACTTCTCCCCCCACGTGGCACTGGAG TGTGAACTGGCTCATTCTGGACACCAGCATGGAGCCAGCACGGGAACAGGGGGGCAGCCT AGAGCACAAGCTCTATCTGTGTCCTTCAGAGCTCCTGGGAAACATGATGCGCCCTCATGG GAATGGCATTTTGCATATCACACAGGCTGTCCTGGGAGTCAGGCAGACTGGATTGTCACG TGCGGTGTGCATGCAGCAGCTTGTGCACTGCAGTGGACCTGTGGACCATTTCTAAAGGTG CACAACANATAATAAATGTGTCCTTCTTTGTTTTTTAAAAAAAAAAAAAAAAACTCGAGT TNTTTTTTTTTTTTTTTTTTNNNTTNTTNNNNNNTTTTTTTTTTTTTTGAGAAGCCTGTG GTTTATTGAAAAGAGCAAGGCTGGTGGGGCGTGGGACTCAAAAACATGGCAACGGGCAAA GGCCTGGAACAATTGGGGATTCTTCAACTTCTTAAATGCTAATTACCCAGTGGAGCTTTG GGCTATTTTTTTCAG
Restriction Sites	Please inquire
ACCN	BC007382
Insert Size	564 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC007382.1
RefSeq Size	564 bp
Locus ID	338382
Protein Families	Druggable Genome
Gene Summary	Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.[UniProtKB/Swiss-Prot Function]

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