ALS (IGFALS) (NM_004970) Human Untagged Clone
CAT＃: SC122694
IGFALS (untagged)-Human insulin-like growth factor binding protein, acid labile subunit (IGFALS), transcript variant 2
CNY 4512.00
CNY 7220.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ACLSD; ALS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004970 edited
GGAAATCCAGAGGGCAGGGGTGGCCGGCACAGCAGACGTACCCTCCCTCGCTGCCTGCCT GCAGCCTGCCCTGCATGCAGGATGGCCCTGAGGAAAGGAGGCCTGGCCCTGGCGCTGCTG CTGCTGTCCTGGGTGGCACTGGGCCCCCGCAGCCTGGAGGGAGCAGACCCCGGAACGCCG GGGGAAGCCGAGGGCCCAGCGTGCCCGGCCGCCTGTGTCTGCAGCTACGATGACGACGCG GATGAGCTCAGCGTCTTCTGCAGCTCCAGGAACCTCACGCGCCTGCCTGATGGAGTCCCG GGCGGCACCCAAGCCCTGTGGCTGGACGGCAACAACCTCTCGTCCGTCCCCCCGGCAGCC TTCCAGAACCTCTCCAGCCTGGGCTTCCTCAACCTGCAGGGCGGCCAGCTGGGCAGCCTG GAGCCACAGGCGCTGCTGGGCCTAGAGAACCTGTGCCACCTGCACCTGGAGCGGAACCAG CTGCGCAGCCTGGCACTCGGCACGTTTGCACACACGCCCGCGCTGGCCTCGCTCGGCCTC AGCAACAACCGTCTGAGCAGGCTGGAGGACGGGCTCTTCGAGGGCCTCGGCAGCCTCTGG GACCTCAACCTCGGCTGGAATAGCCTGGCGGTGCTCCCCGATGCGGCGTTCCGCGGCCTG GGCAGCCTGCGCGAGCTGGTGCTGGCGGGCAACAGGCTGGCCTACCTGCAGCCCGCGCTC TTCAGCGGCCTGGCCGAGCTCCGGGAGCTGGACCTGAGCAGGAACGCGCTGCGGGCCATC AAGGCAAACGTGTTCGTGCAGCTGCCCCGGCTCCAGAAACTCTACCTGGACCGCAACCTC ATCGCTGCCGTGGCCCCGGGCGCCTTCCTGGGCCTGAAGGCGCTGCGATGGCTGGACCTG TCCCACAACCGCGTGGCTGGCCTCCTGGAGGACACGTTCCCCGGTCTGCTGGGCCTGCGT GTGCTGCGGCTGTCCCACAACGCCATCGCCAGCCTGCGGCCCCGCACCTTCAAGGACCTG CACTTCCTGGAGGAGCTGCAGCTGGGCCACAACCGCATCCGGCAGCTGGCTGAGCGCAGC TTTGAGGGCCTGGGGCAGCTTGAGGTGCTCACGCTAGACCACAACCAGCTCCAGGAGGTC AAGGCGGGCGCTTTCCTCGGCCTCACCAACATGGCGGTCATGAACCTCTCTGGGAACTGT CTCCGGAACCTTCCGGAGCAGGTGTTCCGGGGCCTGGGCAAGCTGCACAGCCTGCACCTG GAGGGCAGCTGCCTGGGACGCATCCGCCCGCACACCTTCACCGGCCTCTCGGGGCTCCGC CGACTCTTCCTCAAGGACAACGGCCTCGTGGGCATTGAGGAGCAGAGCCTGTGGGGGCTG GCGGAGCTGCTGGAGCTCGACCTGACCTCCAACCAGCTCACGCACCTGCCCCACCGCCTC TTCCAGGGCCTGGGCAAGCTGGAGTACCTGCTGCTCTCCCGCAACCGCCTGGCAGAGCTG CCGGCGGACGCCCTGGGCCCCCTGCAGCGGGCCTTCTGGCTGGACGTCTCGCACAACCGC CTGGAGGCATTGCCCAACAGCCTCTTGGCACCACTGGGGCGGCTGCGCTACCTCAGCCTC AGGAACAACTCACTGCGGACCTTCACGCCGCAGCCCCCGGGCCTGGAGCGCCTGTGGCTG GAGGGTAACCCCTGGGACTGTGGCTGCCCTCTCAAGGCGCTGCGGGACTTCGCCCTGCAG AACCCCAGTGCTGTGCCCCGCTTCGTCCAGGCCATCTGTGAGGGGGACGATTGCCAGCCG CCCGCGTACACCTACAACAACATCACCTGTGCCAGCCCGCCCGAGGTCGTGGGGCTCGAC CTGCGGGACCTCAGCGAGGCCCACTTTGCTCCCTGCTGACCAGGTCCCCGGACTCAAGCC CCGGACTCAGGCCCCCACCTGGCTCACCTTGTGCTGGGGACAGGTCCTCAGTGTCCTCAG GGGCCTGCCCAGTGCACTTGCTGGAAGACGCAAGGGCCTGATGGGGTGGAAGGCATGGCG GCCCCCCCAGCTGTCATCAATTAAAGGCAAAGGCAATCGAATCTAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA >OriGene 5' read for NM_004970 unedited
GCGNAATTCCCGGGTATGGAAATCCAGAGTGCAGGGGTGGCCGGCACAGCAGACGTACCC TCCCTCGCTGCCTGCCTGCAGCCTGCCCTGCATGCAGGATGGCCCTGAGGAAAGGAGGCC TGGCCCTGGCGCTGCTGCTGCTGTCCTGGGTGGCACTGGGCCCCCGCAGCCTGGAGGGAG CAGACCCCGGAACGCCGGGGGAAGCCGAGGGCCCAGCGTGCCCGGCCTCCTGTGTCTGCA GCTACGATGACGACGCGGATGAGCTCAGCGTCTTCTGCAGCTCCAGGAACCTCACGCGCC TGCCTGATGGAGTCCCGGGCGGCACCCAAGCCCTGTGGCTGGACGGCAACAACCTCTCGT CCGTCCCCCCGGCAGCCTTCCAGAACCTCTCCAGCCTGGGCTTCCTCAACCTGCAGGGCG GCCAGCTGGGCAGCCTGGAGCCACAGGCGCTGCTGGGCCTAGAGAACCTGTGCCACCTGC ACCTGGAGCGGAACCAGCTGCGCAGCCTGGCACTCGGCACGTTTGCACACACGCCCGCGC TGGCCTCGCTCGGCCTCAGCAACAACCGTCTGAGCAGGCTGGAGGACGGGCTCTTCGAGG GCCTCGGCAGCCTCTGGGACCTCAACCTCGGCTGGAATAGCCTGGCGGTGCTCCCCGATG CGGCGTTCCGCGGCCTGGGCAGCCTGCGCGAGCTGGTGCTGGCGGGCAACAGGCTGGCCT ACCTGCAGCCCGCGCTCTTCAGCGGCCTGGCCGAGCTCCGGGAGCTGGACCTGAGCCAGA ACGCGCTGCGGGCCATCAAGGCAAACGTGTTCGTGCAGCTGCCCCGGCTCCAGAAACTCT ACCTGGACCGCAACCTCATCGCTGCCGTGGGCCCCGG |
| Restriction Sites | Please inquire |
| ACCN | NM_004970 |
| Insert Size | 2168 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004970.1, NP_004961.1 |
| RefSeq Size | 2125 bp |
| RefSeq ORF | 1818 bp |
| Locus ID | 3483 |
| UniProt ID | P35858 |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Expression of acid-labile subunit (als) in developing and adult zebrafish and its role in dorso-ventral patterning during development
,Landi, E;Karabatas, L;Scaglia, P;Pisciottano, F;Gutierrez, M;Ramirez, L;Bergadá, I;Rey, R;Guillermo Jasper, H;Mario Domené, H;Viviana Plazas, P;Domené, S;,
Gen. Comp. Endocrinol.
,PubMed ID 32828812
[IGFALS]
|
|
Assessment of pathogenicity of natural IGFALS gene variants by in silico bioinformatics tools and in vitro functional studies
,Martucci, LC;Gutiérrez, ML;Karabatas, LM;Scaglia, PA;Rey, RA;Domené, HM;Jasper, HG;Domené, S;,
Mol. Cell. Endocrinol.
,PubMed ID 27018247
[IGFALS]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206542 | IGFALS (Myc-DDK-tagged)-Human insulin-like growth factor binding protein, acid labile subunit (IGFALS), transcript variant 2 |
CNY 4504.00 |
|
| RC206542L3 | Lenti ORF clone of Human insulin-like growth factor binding protein, acid labile subunit (IGFALS), transcript variant 2, Myc-DDK-tagged |
CNY 5890.00 |
|
| RC206542L4 | Lenti ORF clone of Human insulin-like growth factor binding protein, acid labile subunit (IGFALS), transcript variant 2, mGFP tagged |
CNY 5890.00 |
|
| RG206542 | IGFALS (tGFP-tagged) - Human insulin-like growth factor binding protein, acid labile subunit (IGFALS), transcript variant 2 |
CNY 6104.00 |
