MACROD1 (BC003188) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	LRP16; MACRO domain containing 1
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC003188 edited GTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGG CGTGGGGGGCGGCGGCGGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCA TGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGCGAAATCCTTTCTGA AGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGA AGAAGATCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCA GGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCA AGCTGGAGGTGGACGCCATCGTCAACGCCGCCAACAGCTCCCTGCTCGGAGGCGGTGGCG TGGACGGCTGCATTCATCGGGCCGCCGGCCCCCTGCTTACCGACGAGTGCCGGACCCTGC AGAGCTGTAAGACTGGCAAGGCCAAGATCACCGGCGGCTATCGGCTCCCGGCCAAGTACG TCATCCACACAGTGGGGCCCATCGCCTACGGGGAGCCCAGCGCCAGTCAGGCTGCCGAGC TCCGCAGCTGCTACCTGAGCAGTCTGGACCTGCTGCTGGAGCACCGGCTCCGCTCGGTGG CGTTCCCCTGCATCTCCACCGGCGTGTTTGGCTACCCCTGTGAGGCGGCCGCCGAGATCG TGCTGGCCACGCTGCGAGAGTGGCTGGAGCAGCACAAGGACAAGGTGGACCGGCTGATCA TCTGCGTGTTCCTCGAGAAGGACGAGGACATCTACCGGAGCCGGCTCCCCCACTACTTCC CCGTGGCCTGAGGCTCCCGCAGCCCACCCTGACCGGGACTGACCCGCCTTCGGGACCCCG CTCCCAGCTCTGAGAGGTCGCCAAAGCCTGCAGCCTGGCCTGGGCCTGGCCACCCCTTCT TTCCCTCCGCGCCCCGCCCCCGAGGAGCCTAATAAAGATCTCGTTGTGGCAAAAAAAAAA AAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC003188 unedited NNAATGTCACTATTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGTCCCC CGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGG GGGCGGCGGCGGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGG CGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGCGAAATCCTTTCTGAAGGGCC TGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGA TCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATA AAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCAAGCTGG AGGTGGACGCCATCGTCAACGCCGCCAACAGCTCCCTGCTCGGAGGCGGTGGCGTGGACG GCTGCATTCATCGGGCCGCCGGCCCCCTGCTTACCGACGAGTGCCGGACCCTGCAGAGCT GTAAGACTGGCAAGGCCAAGATCACCGGCGGCTATCGGCTCCCGGCCAAGTACGTCATCC ACACAGTGGGGCCCATCGCCTACGGGGAGCCCAGCGCCAGTCAGGCTGCCGAGCTCCGCA GCTGCTACCTGAGCAGTCTGGACCTGCTGCTGGAGCACCGGCTCCGCTCGGTGGCGTTCC CCTGCATCTCCACCGGCGTGTTTGGCTACCCCTGTGAGGCGGCCGCCGAGATCGTGCTGG CCACGCTGCGAGAGTGGCTGGAGCAGCACAAGGACAAGGTGGNACCGGCTGATCATCTGC GTGTTCCTCGAGAATGACGAGGACATCTACCGGAGCCNGGCTNCNCACTACTTNCCCGTG GC
Restriction Sites	Please inquire
ACCN	BC003188
Insert Size	1031 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC003188.1, AAH03188.1
RefSeq Size	1031 bp
Locus ID	28992
Gene Summary	Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104).[UniProtKB/Swiss-Prot Function]

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