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LOXL2 (NM_002318) Human Untagged Clone
CAT＃: SC118675
LOXL2 (untagged)-Human lysyl oxidase-like 2 (LOXL2)
CNY 8,512.00
| Cited in 6 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | LOR; LOR2; WS9-14 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118675 sequence for NM_002318 edited (data generated by NextGen Sequencing)
ATGGAGAGGCCTCTGTGCTCCCACCTCTGCAGCTGCCTGGCTATGCTGGCCCTCCTGTCC CCCCTGAGCCTGGCACAGTATGACAGCTGGCCCCATTACCCCGAGTACTTCCAGCAACCG GCTCCTGAGTATCACCAGCCCCAGGCCCCCGCCAACGTGGCCAAGATTCAGCTGCGCCTG GCTGGGCAGAAGAGGAAGCACAGCGAGGGCCGGGTGGAGGTGTACTATGATGGCCAGTGG GGCACCGTGTGCGATGACGACTTCTCCATCCACGCTGCCCACGTCGTCTGCCGGGAGCTG GGCTATGTGGAGGCCAAGTCCTGGACTGCCAGCTCCTCCTACGGCAAGGGAGAAGGGCCC ATCTGGTTAGACAATCTCCACTGTACTGGCAACGAGGCGACCCTTGCAGCATGCACCTCC AATGGCTGGGGCGTCACTGACTGCAAGCACACGGAGGATGTCGGTGTGGTGTGCAGCGAC AAAAGGATTCCTGGGTTCAAATTTGACAATTCGTTGATCAACCAGATAGAGAACCTGAAT ATCCAGGTGGAGGACATTCGGATTCGAGCCATCCTCTCAACCTACCGCAAGCGCACCCCA GTGATGGAGGGCTACGTGGAGGTGAAGGAGGGCAAGACCTGGAAGCAGATCTGTGACAAG CACTGGACGGCCAAGAATTCCCGCGTGGTCTGCGGCATGTTTGGCTTCCCTGGGGAGAGG ACATACAATACCAAAGTGTACAAAATGTTTGCCTCACGGAGGAAGCAGCGCTACTGGCCA TTCTCCATGGACTGCACCGGCACAGAGGCCCACATCTCCAGCTGCAAGCTGGGCCCCCAG GTGTCACTGGACCCCATGAAGAATGTCACCTGCGAGAATGGGCTACCGGCCGTGGTGAGT TGTGTGCCTGGGCAGGTCTTCAGCCCTGACGGACCCTCAAGATTCCGGAAAGCGTACAAG CCAGAGCAACCCCTGGTGCGACTGAGAGGCGGTGCCTACATCGGGGAGGGCCGCGTGGAG GTGCTCAAAAATGGAGAATGGGGGACCGTCTGCGACGACAAGTGGGACCTGGTGTCGGCC AGTGTGGTCTGCAGAGAGCTGGGCTTTGGGAGTGCCAAAGAGGCAGTCACTGGCTCCCGA CTGGGGCAAGGGATCGGACCCATCCACCTCAACGAGATCCAGTGCACAGGCAATGAGAAG TCCATTATAGACTGCAAGTTCAATGCCGAGTCTCAGGGCTGCAACCACGAGGAGGATGCT GGTGTGAGATGCAACACCCCTGCCATGGGCTTGCAGAAGAAGCTGCGCCTGAACGGCGGC CGCAATCCCTACGAGGGCCGAGTGGAGGTGCTGGTGGAGAGAAACGGGTCCCTTGTGTGG GGGATGGTGTGTGGCCAAAACTGGGGCATCGTGGAGGCCATGGTGGTCTGCCGCCAGCTG GGCCTGGGATTCGCCAGCAACGCCTTCCAGGAGACCTGGTATTGGCACGGAGATGTCAAC AGCAACAAAGTGGTCATGAGTGGAGTGAAGTGCTCGGGAACGGAGCTGTCCCTGGCGCAC TGCCGCCACGACGGGGAGGACGTGGCCTGCCCCCAGGGCGGAGTGCAGTACGGGGCCGGA GTTGCCTGCTCAGAAACCGCCCCTGACCTGGTCCTCAATGCGGAGATGGTGCAGCAGACC ACCTACCTGGAGGACCGGCCCATGTTCATGCTGCAGTGTGCCATGGAGGAGAACTGCCTC TCGGCCTCAGCCGCGCAGACCGACCCCACCACGGGCTACCGCCGGCTCCTGCGCTTCTCC TCCCAGATCCACAACAATGGCCAGTCCGACTTCCGGCCCAAGAACGGCCGCCACGCGTGG ATCTGGCACGACTGTCACAGGCACTACCACAGCATGGAGGTGTTCACCCACTATGACCTG CTGAACCTCAATGGCACCAAGGTGGCAGAGGGCCACAAGGCCAGCTTCTGCTTGGAGGAC ACAGAATGTGAAGGAGACATCCAGAAGAATTACGAGTGTGCCAACTTCGGCGATCAGGGC ATCACCATGGGCTGCTGGGACATGTACCGCCATGACATCGACTGCCAGTGGGTTGACATC ACTGACGTGCCCCCTGGAGACTACCTGTTCCAGGTTGTTATTAACCCCAACTTCGAGGTT GCAGAATCCGATTACTCCAACAACATCATGAAATGCAGGAGCCGCTATGACGGCCACCGC ATCTGGATGTACAACTGCCACATAGGTGGTTCCTTCAGCGAAGAGACGGAAAAAAAGTTT GAGCACTTCAGCGGGCTCTTAAACAACCAGCTGTCCCCGCAGTAA Clone variation with respect to NM_002318.2 306 c=>t >OriGene 5' read for NM_002318 unedited
TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGAAAAGAGTAAA CGCGCGNACTCCGCGCGCGGCTACCTACGCTTGGTGCTTGCTTTCTCCAGCCATTGGAGA CCAGAGCCGCCCCCTCTGCTCGAGAAAGGGGCTCAGCGGCGGCGGAAGCGGAGGGGGACC ACCGTGGAGAGCGCGGTCCCAGCCCGGCCACTGCGGATCCCTGAAACCAAAAAGCTCCTG CTGCTTCTGTACCCCGCCTGTCCCTCCCAGCTGCGCAGGGCCCCTTCGTGGGATCATCAG CCCGAAGACAGGGATGGAGAGGCCTCTGTGCTCCCACCTCTGCAGCTGCCTGGCTATGCT GGCCCTCCTGTCCCCCCTGAGCCTGGCACAGTATGACAGCTGGCCCCATTACCCCGAGTA CTTCCAGCAACCGGCTCCTGAGTATCACCAGCCCCAGGCCCCCGCCAACGTGGCCAAGAT TCAGCTGCGCCTGGCTGGGCAGAAGAGGAAGCACAGCGAGGGCCGGGTGGAGGTGTACTA TGATGGCCAGTGGGGCACCGTGTGCGATGACCACTTCTCCATCCACGCTGCCCACGTCGT CTGCCGGGAGCTGGGCTATGTGGAGGCCAAGTCCTGGACTGCCAGCTCCTCCTACGGCAA GGGAGAAGGGGCCATCTGGTTAGACAATCTCCACTGTACTGGCAACGAGGCGACCCTTGC AGCATGCACCTTCAATGGCTGGGGCGTCACTGACTGCAGCACACGGAGGATTGTCGTGTG GTGTGCCACGACAAAAGGATTCCTGGGNTTAAATTTGCCATTTCGTTGACCACCCAGATA GAGACCTGGATT >OriGene 3' read for NM_002318 unedited
CGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTAATAAATCTTTCTTTTATTCCAAGT TTCAAGTATGTGTAAGTGTCTGTGATGACACATGGTGCTCAGTGAGCGCCCTGTCACCCA GGACCCTGGTTATAGCACCGTTGAATCAAAAACCCACAGAATTGGAACAACAGGAAGATG AGTCACTTACACAGTGGGTTGGTTTTTCCTTAAATTTGTACTTCCAAGGGCCCAGATGTC CAATATTAAATGCCAATAAATTTGTGCTTCAAAAGTCTGTGAAAATATAATAATAGTATC TTGAAAAACAAGGGGTGGGGGTTGTGGAGAGGGAAGCACCAAGTCTGAGCTCACCAAATC AGAAAACACGTGGCACCATTATCTATGTGACTATAATAGACTGGAGGGTTTCATTGGAAG AGAGGTCTAGATATTCAAGTTTGCTGAAAATGACCTAAGAGGAGGAGAAATGGGGTTCGG CCTGACCCTCTCTGGGGGGGCTGATGAGCCCGCATTTGTCCACGTGTCACTGGAGAAGAG CGCGGCTCCACTGTGTCTGTGGTGAGCTCGGTGGCTTGAATGGGACAAGCTGATGACAAC CTGTCTGTGGGCCTCATCCCGGTCAAGACTGGCTCTTGGTGCTGCTCCAGCAGCTCTGTG GACAAACCCCACCCCCCCAAGGCCTTCTCATGCCCCCAAGGGTCAGGTAGCAGCCCTCCA TGAATGATGGGAGGGTCCCTTTCCTCCTGAGCTTAACACAGCTGTAGGGGTCTGGACAGG TGGAGGCCAGGCCTGGTGAGGGCACGTGGCATTCGTTCAGACTCAGTTGGTGGNGGGGAA GTCCCATGGNATATGTGGTGCGGCCCCTGATACAAGATTGACCACCCAGGCTTCTTACTG AGAGACAGCTGGTTGTTAATAACCCGTGAAAGCTCAAACTTCTTTCGTTCTTGCTGAAGA CCCCTAGGGCAGTTGACTCAAATGGGGGCGCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002318 |
| Insert Size | 3550 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002318.2, NP_002309.1 |
| RefSeq Size | 3810 bp |
| RefSeq ORF | 2325 bp |
| Locus ID | 4017 |
| UniProt ID | Q9Y4K0 |
| Domains | SR, Lysyl_oxidase |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition
,de Jong, OG;van der Waals, LM;Kools, FRW;Verhaar, MC;van Balkom, BWM;,
J. Cell. Physiol.
,PubMed ID 30387148
[LOXL2]
|
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Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2
,de Jong, OG;van Balkom, BW;Gremmels, H;Verhaar, MC;,
J. Cell. Mol. Med.
,PubMed ID 26612622
[LOXL2]
|
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Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma
,Nishikawa, R;Chiyomaru, T;Enokida, H;Inoguchi, S;Ishihara, T;Matsushita, R;Goto, Y;Fukumoto, I;Nakagawa, M;Seki, N;,
FEBS Lett.
,PubMed ID 26096783
[LOXL2]
|
|
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
,Wong, CC;Tse, AP;Huang, YP;Zhu, YT;Chiu, DK;Lai, RK;Au, SL;Kai, AK;Lee, JM;Wei, LL;Tsang, FH;Lo, RC;Shi, J;Zheng, YP;Wong, CM;Ng, IO;,
Hepatology July 2014
,PubMed ID 25048396
[LOXL2]
|
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Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted from Drosophila S2 Cells
,Li Xu, Eden P. Go, Joel Finney, HeeJung Moon, Mason Lantz, Kathryn Rebecchi, Heather Desaire, and Minae Mure,
J. Biol. Chem., Feb 2013; 288: 5357 - 5363.
[LOXL2]
|
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Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane
,Marine Bignon, Cathy Pichol-Thievend, Julie Hardouin, Marilyne Malbouyres, Nicolas Bréchot, Luiz Nasciutti, Alain Barret, Jérémie Teillon, Emilie Guillon, Eric Etienne, Michel Caron, Raymonde Joubert-Caron, Catherine Monnot, Florence Ruggiero, Laurent Muller, and Stéphane Germain,
Blood, Oct 2011; 118: 3979 - 3989.
[LOXL2]
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Resources
Other Versions
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|---|---|---|---|
| RC200455 | LOXL2 (Myc-DDK-tagged)-Human lysyl oxidase-like 2 (LOXL2) |
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| RC200455L1 | Lenti ORF clone of Human lysyl oxidase-like 2 (LOXL2), Myc-DDK-tagged |
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| RC200455L2 | Lenti ORF clone of Human lysyl oxidase-like 2 (LOXL2), mGFP tagged |
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| RC200455L3 | Lenti ORF clone of Human lysyl oxidase-like 2 (LOXL2), Myc-DDK-tagged |
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| RC200455L4 | Lenti ORF clone of Human lysyl oxidase-like 2 (LOXL2), mGFP tagged |
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| RG200455 | LOXL2 (tGFP-tagged) - Human lysyl oxidase-like 2 (LOXL2) |
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