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THOC5 (NM_003678) Human Untagged Clone
CAT＃: SC117857
THOC5 (untagged)-Human THO complex 5 (THOC5), transcript variant 4
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C22orf19; Fmip; fSAP79; PK1.3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC117857 sequence for NM_003678 edited (data generated by NextGen Sequencing)
ATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCA GCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGAAGGTAAATACTACAGTGAGGAG GCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAG GAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTG GCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAAAGAAG CTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAG CAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTA CAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATCTGGTC AGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATG GGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGG CTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAG GTGAAGAAGGAGTACCTGAGCAGCCTCNAGCCCCGCCTCAACAGCATCATGCAGGCTTCC CTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACA GCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAG GCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTG TTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAG ACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATG CTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTT CACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACA ACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTC CTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTAT CAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCC TATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACA GTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACTTCTGAAG ACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATT GTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTG AAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGACATTGTG GATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACA GCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTC CAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCGGGCC ATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAG CTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAG AGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGG CTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTC AGCCATCGCTGA Clone variation with respect to NM_003678.4 688 c=>n >OriGene 5' read for NM_003678 unedited
GCACGAGGCGGTTCTCTATGGTGCGCGGGCAAGCTTTGCTCCGCCTCCGGCAGTGGCTTA CTCCCGGTGCCAGGTTCTTGGAGCTGTGAGGAGGAACAACCATGTCATCAGAATCGAGCA AAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATC GATCTGACACCGAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGG ACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGG CTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAAC GGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACA TCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATC ATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAAT GTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATA AGGAGGCTCCAC >OriGene 3' read for NM_003678 unedited
CGGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTCAGGTGACGCTTTTTAATTG GCTGGTGTCTTTGGAGAATATCAAGAGTCACATGTGGGCCAGAGCAGAAAGCAGAAGCCC AGTGCTCAGGGTGAGGCCTTGGGGGAAACAACGGTCTGCGCGGGAGATCAGCGATGGCTG AAGAATCCCTGAGGATGGTTGTATTTAAATGGCTTCATCCTGCTAGGACCCCTGAAGAGC CGCAGACACATCTTCTCCTGGGGAAATTCCTTGGGCCCCTCCACACTGTCGTCATGGCTC TCGGTCTCCAGGTAAACATCCAGCAGCACACACAGCCGCTGCAGCTGGTTGGTCAACAGC TGGTGGCTGGGCCAAGGGCCACACAGCTCCTTGTAGCACACATTGACTTCGCCCTCCATG GCCCGAATGTTGTCATCGTTGCTGTTGGTTTTCTCCCCTTTCCAGTTCAAACAGAGCTGG AAAACAGGTGGGATGGAGGAGTAGCCAGGGTTCAACACCACAGCGGCCTGCAGTTTGGCT GTGCCCCTTTCGATGAGCGCCATGTAGTAGAGATTGGTGTCCCCAGCCAGTCCCGCATCC ANCATGTCTTTGGTGAAGTGCAGCTCCATGNTATCCTCATGGNGCACTGTCACCCATTTC ACCAGGCGAGAGACAACCTTGGCAGGNAAGATGTACTGGNCATCACTGGTAACTGCCACA ATGCCATGTTCTANGGGATGCANNACTGTTGTGGAGGCCCCAGCGGACTGCACCCTGGTC TTCANAAGTTCATGGTGGTCCCATGTGGCTGGCGCTCANCGAGTGGTCAGCATCACTGTT TGCTGGGGCTGCTCTTTGGNGAAGTGGNAGCCACCCAGCTTCTGCACCACAATTAGGGTG ACCTANNCTCAGTCATAGTCCCTCAAGTCAGGATGCCACTTTTTAAACTGAACTGATGGC TG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003678 |
| Insert Size | 2570 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_003678.4, NP_003669.4 |
| RefSeq Size | 2447 bp |
| RefSeq ORF | 2052 bp |
| Locus ID | 8563 |
| UniProt ID | Q13769 |
| Gene Summary | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223375 | THOC5 (Myc-DDK-tagged)-Human THO complex 5 (THOC5), transcript variant 4 |
CNY 3,990.00 |
|
| RC223375L3 | Lenti-ORF clone of THOC5 (Myc-DDK-tagged)-Human THO complex 5 (THOC5), transcript variant 4 |
CNY 5,890.00 |
|
| RC223375L4 | Lenti-ORF clone of THOC5 (mGFP-tagged)-Human THO complex 5 (THOC5), transcript variant 4 |
CNY 5,890.00 |
|
| RG223375 | THOC5 (tGFP-tagged) - Human THO complex 5 (THOC5), transcript variant 4 |
CNY 4,370.00 |
