UBQLN4 (NM_020131) Human Untagged Clone
CAT＃: SC113185
UBQLN4 (untagged)-Human ubiquilin 4 (UBQLN4)
CNY 4480.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | A1U; A1Up; C1orf6; CIP75; UBIN |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC113185 sequence for NM_020131 edited (data generated by NextGen Sequencing)
ATGGCGGAGCCGAGCGGGGCCGAGACGAGGCCCCCCATTCGGGTCACCGTCAAGACCCCC AAGGACAAGGAGGAAATTGTGATCTGCGATCGAGCCTCGGTCAAGGAGTTCAAAGAGGAA ATCTCCCGGAGGTTTAAGGCTCAGCAGGATCAGCTGGTCCTGATCTTCGCAGGCAAGATC CTCAAGGATGGGGACACACTGAACCAGCACGGAATCAAGGACGGGCTCACTGTCCATCTG GTCATCAAGACCCCTCAGAAGGCTCAAGATCCAGCTGCTGCCACTGCTTCTTCCCCCTCC ACACCTGACCCTGCCTCAGCACCCTCCACCACGCCTGCTTCACCCGCCACCCCTGCCCAG CCCTCCACCTCTGGCAGTGCCTCTTCAGATGCTGGCAGTGGAAGCCGGAGGAGCAGTGGT GGGGGGCCCTCTCCGGGGGCTGGGGAGGGATCCCCCAGTGCTACTGCGTCCATACTCTCT GGCTTTGGGGGCATCCTGGGGCTGGGCAGCCTAGGCCTGGGCTCTGCCAACTTCATGGAG CTGCAGCAGCAGATGCAGCGGCAGCTGATGTCCAATCCTGAGATGCTGTCACAGATCATG GAGAACCCCCTGGTCCAGGATATGATGTCTAACCCTGATCTGATGCGTCACATGATTATG GCCAACCCCCAGATGCAGCAGTTGATGGAGCGGAACCCTGAGATCAGCCACATGCTCAAT AACCCTGAACTCATGAGGCAGACAATGGAGCTTGCTCGGAATCCAGCCATGATGCAAGAG ATGATGCGGAACCAGGACCGGGCCCTGAGCAACCTTGAGAGCATCCCTGGAGGGTATAAT GCCCTCCGCCGCATGTACACGGACATCCAGGAGCCCATGTTCAGTGCTGCCCGGGAACAG TTTGGCAACAATCCCTTCTCTTCCCTGGCCGGGAACTCCGACAGCTCATCCTCCCAGCCT CTGCGGACTGAGAATCGAGAGCCCCTCCCTAACCCCTGGAGCCCCTCGCCCCCCACCTCC CATGCCCCCGGGTCCGGTGGGGAGGGCACCGGAGGATCGGGGACCAGCCAGGTGCACCCG ACAGTCTCGAACCCCTTTGGGATCAATGCGGCTAGCCTGGGGTCAGGGATGTTCAATAGC CCAGAAATGCAAGCCCTCCTCCAGCAGATCTCTGAGAACCCCCAGCTGATGCAGAATGTG ATCTCAGCACCCTACATGCGCAGCATGATGCAGACGCTTGCCCAGAACCCCGACTTTGCT GCTCAGATGATGGTGAATGTGCCGCTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTC CGCCTGCAGCTCCCAGTCTTCCTGCAGCAGATGCAGAACCCAGAGTCACTCTCCATCCTT ACCAATCCCCGAGCCATGCAGGCATTGCTGCAGATCCAGCAGGGACTACAGACCTTGCAG ACCGAGGCCCCTGGGCTGGTACCCAGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCA CCCTCAGCAGGCAGCAACGCAGGGTCTACGCCCGAGGCCCCCACTTCCTCACCAGCCACG CCAGCCACATCTTCTCCAACAGGGGCTTCCAGCGCCCAGCAGCAACTCATGCAGCAGATG ATCCAGCTTTTGGCTGGAAGTGGAAACTCACAGGTGCAGACGCCAGAAGTGAGATTTCAG CAGCAGCTGGAGCAGCTCAACTCCATGGGCTTCATCAATCGTGAGGCTAACCTGCAGGCC CTGATTGCCACAGGAGGGGACATCAACGCAGCTATCGAGAGACTGCTGGGCTCCCAGCTC TCCTAA Clone variation with respect to NM_020131.3 1023 g=>t >OriGene 5' read for NM_020131 unedited
CCAATTCCCCCGCCCGTTGACGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATA AGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCC GCGAATTCGGCACGAGGGGCTGGCGGGCGGCCGGGTGGCGGCGGCGGCATGGCGGAGCCG AGCGGGGCCTGAGACGAGGCCCCCCATTCGGGTCACCGTCAAGACCCCCAGGACAAGGAG GAAATTGTGATCTGCGATCGAGCCTCGGTCAAGGAGTTCAAAGAGGAAATCTCCCGGAGG TTTAAGGCTCAGCAGGATCAGCTGGTCCTGATCTTCGCAGGCAAGAGCCTCAAGGATGGG GACACACTGAACCAGCACGGAATCAAGGACGGGCTCACTGTCCATCTGGTCATCAAGACC CCTCAGAAGGCTCAAGAGCCAGCTGCTGCCACTGCTTCTTCCCCCTCCACACCTGACCCT GCCTCAGCACCCTCCACCACGCCTGCTTCACCCGCCACCCCTGCCCAGCCCTCCACCTCT GGCAGTGCCTCTTCAGATGCTGGCAGTGGAAGCCGGAGGAGCAGTGGTGGGGGGCCCTCT CCGGGGGCTGGGGAGGGATCCCCCAGTGCTACTGCGTCCATACTCTCTGGCTTTGGGGGC ATCCTGGGGCTGGGCAGCCTAGGCCTGGGCTCTGCCAACTTCATGGAGCTGCAGCAGCAG ATGCAGCGGCTAGCTGATGTCCAATCCTGAGATGCTGTCACAGATCATGGAGAGCCCCCT GGTCCAGATCATGATGTCTAGCCCTGATCTGATGCGTCCATGGATTATGGCCCACCTCCA GATGCAGCAGTTGATGGGAGCGGAGCCCTGAGATCAGTCCATGCTCAATAGCCCTGACTC ATGAGCAACATTGGAGCTTGCTCGNCATCAGCCTGAGCT >OriGene 3' read for NM_020131 unedited
CGGTCTTACTATGNNACCGCGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTGT TTTTTTTTTTTTCCAACAAAAACCACGCCATTTATTTACAAAGGCCAGTGTGGGAGCTGG GGGAGGCAGGGAGGGAAAGCCACACAGACATCTTCTCTGGACTGCTTGGGACCCTTTCCC ACTTGGAGCAAACTCTGTTCCTCTTGCCGTCATATTCTCAGCCATGGGGTCGGTCCTCCA AGCAGCTGGGCCAAGTAGGAGAGGGAAGAGGTGATATGAGCCTCCTCTGTGCTCTGACAG AGAAATGTCCAATTCCAGATCAAAGGCATTATTGCCACCCTCTCCTCTCCTTCCTCAAAG AAAACTTTCTGGCCTGGAGGGAAATAGTTAAGAACTGAAAGGCCAGGGGCTCTGGAGGAA AAAAAACCCTCTACTATTCCCACAAGGCAGTGAGGGGTGATAAGGGTGCTAGTCACAGCC CTGACAGCTTCAGAAAGGGTACCCACATTACCTCTGGGGTACCCAGCATCCCGAGCCCCA AGGGACCTAGCTCTCCCCGATATATATTCCTGCAATGGACTGACCCTTTTACCCCCTTGT CTCCTGGTGTGGGAGAGCACTCTTGACCCCAAACCAACAGGGGATCCCCTTTCCACCCCA CTTTAGAGAGGTTGCCCACCTGTGGGATACCCAAGCGCCTCCCCCCTTATTTAAAAAAAA CCCCACCCCCTTTATTGTTTTTTTGAGGGGGGGTTCAACATCCTGGGGGCCCGGGGGGAC CCCACCCAAAACCTGTGGGCCCCGGGAAAAGTGTGGTGGGGTGGCCTTTTAAACACCAAT TGCTTTGGGAACTTAAAACCCACTTTTACCCCCCTTGGGGGGGCGGGGGCGCTAATCTCA TTGGGCGCTCTCTTTTCACTTAAAAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_020131 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_020131.3, NP_064516.2 |
| RefSeq Size | 3545 bp |
| RefSeq ORF | 1806 bp |
| Locus ID | 56893 |
| UniProt ID | Q9NRR5 |
| Domains | UBA, UBQ, STI1 |
| Protein Families | Druggable Genome |
| Gene Summary | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209514 | UBQLN4 (Myc-DDK-tagged)-Human ubiquilin 4 (UBQLN4) |
CNY 4472.00 |
|
| RC209514L1 | Lenti ORF clone of Human ubiquilin 4 (UBQLN4), Myc-DDK-tagged |
CNY 6872.00 |
|
| RC209514L2 | Lenti ORF clone of Human ubiquilin 4 (UBQLN4), mGFP tagged |
CNY 6460.00 |
|
| RC209514L3 | Lenti ORF clone of Human ubiquilin 4 (UBQLN4), Myc-DDK-tagged |
CNY 6460.00 |
|
| RC209514L4 | Lenti ORF clone of Human ubiquilin 4 (UBQLN4), mGFP tagged |
CNY 6460.00 |
|
| RG209514 | UBQLN4 (tGFP-tagged) - Human ubiquilin 4 (UBQLN4) |
CNY 6072.00 |
