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PFKFB4 (NM_004567) Human Untagged Clone
CAT＃: SC110972
PFKFB4 (untagged)-Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4)
CNY 2,950.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110972 sequence for NM_004567 edited (data generated by NextGen Sequencing)
ATGGCGTCCCCACGGGAATTGACACAGAACCCCCTGAAGAAGATCTGGATGCCATACAGC AATGGGCGGCCCGCTCTGCACGCTTGCCAGCGCGGTGTGTGCATGACCAACTGCCCAACT CTCATTGTCATGGTGGGCCTGCCCGCCAGGGGCAAGACCTACATCTCCAAGAAGCTGACT CGATACCTGAACTGGATTGGTGTGCCCACTCGGGAGTTCAATGTTGGCCAGTATCGCCGG GACGTGGTCAAGACCTACAAATCTTTTGAATTTTTTCTCCCCGACAATGAAGAGGGCCTG AAAATCAGGAAGCAGTGTGCCCTGGCAGCCCTCCGTGACGTCCGGCGGTTCCTTAGTGAG GAGGGGGGACATGTGGCGGTTTTTGATGCCACAAACACCACCCGAGAACGGAGAGCGACC ATCTTTAATTTTGGAGAACAGAATGGCTACAAGACCTTTTTTGTCGAGTCCATCTGTGTG GATCCTGAGGTCATAGCTGCCAACATCGTGCAAGTGAAACTGGGCAGCCCTGACTATGTC AACCGCGACAGTGATGAGGCTACGGAGGACTTCATGAGGCGCATTGAGTGCTATGAGAAC TCCTACGAGTCGCTAGATGAGGACCTGGATAGGGACCTGTCCTATATCAAGATCATGGAT GTGGGCCAGAGCTACGTGGTGAACCGTGTGGCTGACCACATCCAGAGCCGCATCGTATAT TACCTCATGAACATCCACGTGACCCCCCGCTCCATCTACCTCTGCCGGCACGGGGAGAGC GAGCTCAACCTCAAGGGCCGGATTGGCGGGGACCCAGGACTGTCCCCTCGGGGCAGGGAG TTTGCCAAGAGTCTAGCCCAGTTCATCAGTGACCAAAATATCAAGGATCTGAAGGTCTGG ACAAGCCAGATGAAGAGGACAATCCAGACGGCTGAGGCACTGGGTGTGCCCTATGAACAG TGGAAGGTCCTCAACGAGATCGATGCGGGCGTCTGTGAGGAAATGACCTACGAGGAAATT CAGGATAATTATCCACTGGAGTTCGCCCTGCGGGACCAGGACAAGTACCGGTACCGGTAC CCTAAAGGGGAGTCCTACGAGGACCTGGTCCAGAGACTGGAGCCTGTCATCATGGAGCTG GAGAGGCAAGAGAATGTGCTGGTCATCTGCCACCAGGCTGTGATGCGCTGCCTGCTGGCC TACTTCCTCGACAAGGCAGCAGAACAGCTGCCCTACCTCAAGTGTCCGCTGCACACAGTC CTGAAGCTGACTCCTGTGGCATATGGTTGTAAAGTGGAGTCCATATTCCTGAACGTGGCT GCTGTGAACACGCACCGGGACAGGCCTCAGAACGTGGACATCTCAAGACCTCCAGAGGAA GCCCTTGTCACGGTGCCTGCTCACCAGTGA Clone variation with respect to NM_004567.2 >OriGene 5' read for NM_004567 unedited
GCGATTTGTATACGACTCCTATAGGCGGCCGCGNAATTCGCACGAGGAGGTGGCCCGGCT GCTGGGTTGGAAGCGGCGCAGTCCGACTCATCCCGGCCCCGGGATGGCGTCCCCACGGGN AATTGACACAGAACCCCCTGAAGAAGATCTGGATGCCATACAGCAATGGGCGGCCCGGTC TGCACGCTTGCCAGCGCGGTGTGTGCATGACCAACTGCCCAACTCTCATTGTCATGGTGG GCCTGCCCGCCAGGGGCAAGACCTACATCTCCAAGAGGCTGACTCGATACCTGAACTGGA TTGGTGTGCCCACTCGGGAGTTCAATGTTGGCCAGTATCGCCGGGACGTGGTCAAGACCT ACAAATCTTTTGAATTTTTTCTCCCCGACAATGAAGAGGGCCTGAAAATCAGGAAGCAGT GTGCCCTGGCAGCCCTCCGTGACGTCCGGCGGTTCCTTAGTGAGGAGGGGGGACATGTGG CGGTTTTTGATGCCACAAACACCACCCGAGAACGGAGAGCGACCATCTTTAATTTTGGAG AACAGAATGGCTACAAGACCTTTTTTGTCGAGTCCATCTGTGTGGATCCTGAGGTCATAG CTGCCAACATCGTGCAAGTGAAACTGGGCAGCCCTGACTATGTCAACCGCGACAGTGATG AGGCTACCGAGGACTTCATGAGGCGCATTGAGTGCTATGAGAACTCCTACCAGTCGCTAG ATGAGGACCCTGATAGGGACCTGTCCTATATAAGATCATGGATGTGGGCCCAGAGCTACG TGGTGAACCGTGTGGCTGACCCCATCCCGACCCGAACGTATATTACCTCATGAACATTCC ACGTGACCCCCGGTCCATCTACCTTGGNCGGAACGGGGAGAGCGAGGCTAACCTCCAGGC GCGCGATGGTGGGGACCCAGACTGTCCCCTCGGGCAGGTAGTTTGCCAGAGTTTC >OriGene 3' read for NM_004567 unedited
AGCTATGGACCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTAT TTTTTAAAAAGTATTTATTGCAAAGAATGCTGGCACACAGTGTTGCATGTGGCTGAGATT CAATACCATCCATTCTGGGGAACTCGGGAAAATATCTGCAACATGGGCACGCCAGCCAGC ATGGCCGAAATGTGGCAGCCAATCAGCTACACCTCAGCCCATGCGGAGACCATGCCAGGG CAGAGGCCGGGGGGTTGCCCCCACTCATGCCCTGATCCCTGGATGTCCCTCTACCCTGTC CCCAGTCCTCGTAATGCATCCAGTCCAGCAACTCCTAACTCCCCTCTGTACACAGAGAGA AAAGGCCTCGGCGGTCTCACCTCAGATGACATCCAGAGGTACATGCACTGTTGCTGACCA AGGGAACCCACTATGGCTAACAAATGAGTGTGTCCAGGTGACAAAAGTCACCAAAACTCC AAAATACACAGAAGCAAAGGCTGCACTCCTAATGTCCCAAAGGCATGGTCCTTGGGCTCT GGGTCTAAAGGGCTTGGGGCTCTCACACAGAATCTGGAGGATCTTGCCCCCGGTCCCCCT GGACATTTCTTACCGAGCCCCCCCAGGCTGAGACACACCGACCCGGGCACGGGCCCTATC TTCAGTCGCGCTCCGGGGAGCTCTCGGGACTCGCCTAACCCGGGAACCTGGAAATATCGC CCTCCCTTTCGACATTGAACATCACGGGCGCGCGCGCCAGAGGCCACTCCCTCCATGGCA CCCGCCTACACGCCTCGTCGCCCCTTTCACCCATACCGACCCTCATCAACCGCCCCAACC CTACAATATTCACTCTACATCACCACACAACACCATTGTCACGTAACACCCGCACACCCC TCAGATTCCGCCGCCGGCCGGTCCCTGCTCCTTGGCCAGTACNAGCATCTAGCCGTACTC CACCCGCGTC |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_004567 |
| Insert Size | 3630 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_004567.2, NP_004558.1 |
| RefSeq Size | 3503 bp |
| RefSeq ORF | 1410 bp |
| Locus ID | 5210 |
| UniProt ID | Q16877 |
| Domains | PGAM, 6PF2K |
| Protein Families | Druggable Genome |
| Protein Pathways | Fructose and mannose metabolism |
| Gene Summary | The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Transcript Variant: This variant (2) lacks an alternate coding exon in the 5' end compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors
,null,
The Journal of Clinical Endocrinology and Metabolism
,PubMed ID 34791326
[PFKFB4]
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Documents
| Product Manuals |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201573 | PFKFB4 (Myc-DDK-tagged)-Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) |
CNY 3,656.00 |
|
| RC201573L1 | Lenti ORF clone of Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201573L2 | Lenti ORF clone of Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), mGFP tagged |
CNY 5,890.00 |
|
| RC201573L3 | Lenti ORF clone of Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201573L4 | Lenti ORF clone of Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), mGFP tagged |
CNY 5,890.00 |
|
| RG201573 | PFKFB4 (tGFP-tagged) - Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) |
CNY 4,370.00 |
|
| SC323929 | PFKFB4 (untagged)-Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) |
CNY 2,950.00 |
