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p107 (RBL1) (NM_002895) Human Untagged Clone
CAT＃: SC109714
RBL1 (untagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1
CNY 11,168.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CP107; p107; PRB1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC109714 sequence for NM_002895 edited (data generated by NextGen Sequencing)
ATGTTCGAGGACAAGCCCCACGCTGAGGGGGCGGCGGTGGTCGCCGCAGCCGGGGAGGCG CTACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGCCCTGGAC GACTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCA TGTTCATTATATGTTGCATGCCGCAAAAGCATTATTCCCACGGTTGGAAAGGGTATCATG GAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTTAATACAA TTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTGAA CGTATAGAAAGGCTAGAGAGAAATTTTGAGGTGTCTACTGTAATATTCAAAAAATATGAG CCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACCACGAAGC CGGAAGCAGAGGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTT TTTGTTTATACTAAGGGTAATTTTCGGATGATTGGGGATGACTTAGTAAACTCTTATCAT TTACTTCTATGCTGCTTGGATCTGATTTTTGCCAATGCGATTATGTGCCCAAATAGACAA GACTTGCTAAATCCATCATTTAAAGGTTTACCATCTGATTTTCATACTGCTGACTTTACG GCTTCTGAAGAGCCACCCTGCATCATTGCTGTACTGTGTGAACTGCATGATGGACTTCTC GTAGAAGCAAAAGGAATAAAGGAGCACTACTTTAAGCCATATATTTCAAAACTCTTTGAC AGGAAGATATTAAAAGGAGAATGCCTCCTGGACCTTTCAAGTTTTACTGATAATAGCAAA GCAGTGAATAAGGAGTATGAAGAGTATGTTCTAACTGTTGGTGATTTTGATGAGAGGATC TTTTTGGGAGCAGACGCAGAAGAGGAAATTGGAACACCTCGAAAGTTCACTCGTGACACC CCATTAGGGAAACTGACAGCACAGGCTAATGTGGAGTATAACCTTCAACAGCACTTTGAA AAAAAAAGGTCATTTGCACCTTCTACCCCACTGACCGGACGGAGATATTTACGAGAAAAA GAAGCAGTCATTACTCCTGTTGCATCAGCCACCCAAAGTGTGAGCCGGTTACAGAGTATT GTGGCTGGTCTGAAAAATGCACCAAGTGACCAACTTATAAATATTTTTGAATCTTGTGTG CGTAATCCTGTGGAAAACATTATGAAAATACTAAAAGGAATAGGAGAGACTTTCTGTCAA CACTATACTCAATCAACAGATGAACAGCCAGGATCTCACATAGACTTTGCTGTAAACAGA CTAAAGCTGGCAGAAATTTTGTATTATAAAATACTAGAGACTGTAATGGTTCAGGAAACA CGAAGACTTCATGGAATGGACATGTCAGTTCTTTTAGAGCAAGATATATTTCATCGTTCC TTGATGGCTTGTTGTTTGGAAATTGTGCTCTTTGCCTATAGCTCACCTCGTACTTTTCCT TGGATTATTGAAGTTCTCAACTTGCAACCATTTTACTTTTATAAGGTTATTGAGGTGGTG ATCCGCTCAGAAGAGGGGCTCTCAAGGGACATGGTGAAACACCTAAACAGCATTGAAGAA CAGATTTTGGAGAGTTTAGCATGGAGTCACGATTCTGCACTGTGGGAGGCTCTCCAGGTT TCTGCAAACAAAGTTCCTACCTGTGAAGAAGTTATATTCCCAAATAACTTTGAAACAGGA AATGGAGGAAATGTGCAGGGACATCTTCCCCTGATGCCAATGTCTCCTCTAATGCACCCA AGAGTCAAGGAAGTTCGAACTGACAGTGGGAGTCTTCGAAGAGATATGCAACCATTGTCT CCAATTTCTGTCCATGAACGCTACAGTTCTCCTACCGCAGGGAGTGCTAAGAGAAGACTC TTTGGAGAGGACCCCCCAAAGGAAATGCTTATGGACAAGATCATAACAGAAGGAACAAAA TTGAAAATCGCTCCTTCTTCAAGCATTACTGCTGAAAATGTATCAATTTTACCTGGTCAA ACTCTTCTAACAATGGCCACAGCCCCAGTAACAGGAACAACAGGACATAAAGTTACAATT CCATTACATGGTGTCGCAAATGATGCTGGAGAGATCACACTGATACCTCTTTCCATGAAT ACAAATCAGGAGTCCAAAGTCAAGAGTCCTGTATCACTTACTGCTCATTCATTAATTGGT GCTTCTCCAAAACAGACCAATCTGACTAAAGCACAAGAGGTACATTCAACTGGAATAAAC AGGCCAAAGAGAACTGGGTCCTTAGCACTATTTTACAGAAAGGTCTATCATTTGGCAAGT GTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATA TGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTG GATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACT TTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGA AGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGAT GACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGT GGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGA AGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCT CCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCC CAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGC GCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATG ATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAA TCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGAT GTTGTCAGTGAAAGAGCAAATCATTAA Clone variation with respect to NM_002895.2 >OriGene 5' read for NM_002895 unedited
CGGCCGCGAATTCGGCACGAGAAGTCGGGGGCCGTGGCGCGCAGCCCGCGGGGCCTGAAG GGATGTTCGAGGACAAGCCCCACGCTGAGGGGGCGGCGGTGGTCGCCGCAGCCGGGGAGG CGCTACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGCCCTGG ACGACTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGG CATGTTCATTATATGTTGCATGCCGCAAAAGCATTATTCCCACGGTTGGAAAGGGTATCA TGGAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTTAATAC AATTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTG AACGTATAGAAAGGCTAGAGAGAAATTTTGAGGTGTCTACTGTAATATTCAAAAAATATG AGCCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACCACGAA GCCGGAAGCAGAGGAGGATTCCTTGCAGGGTTAAGGATCTGTTTAATTTCTGGTGGACAC TTTTTGGTTATACTAAGGGTAATTTTCGGATGATTGGGGATGACTTAGTAAACTCTTATC ATTTACTTCTATGCTGGCTGGATCTGAATTTTGCGCATGCGATTATGTGCCCAATAGACA AGACTTGCTAATTCATCATTAN >OriGene 3' read for NM_002895 unedited
CGCCCAATACGGTGTGCACACGCCCAATTTCGAGGATCNATTTTTCCCTTTTTTTTTTTT TCCAATCCTTTTTTATAGCCTTCTAGTACTTGAACCAATCCTGAAAACTGAAAAAACTGT CCAGAATTCTTTTTTTCCTTTTCTGAAAAAGGTCTTGCCCTCTCACCTAGGATGGAGTGT AGTGGTGCAATCACAGCTCACTGCAGCCTCAAAATCTCCCAGTCTCAAGTGATCCTCTCA TGTCAGTCTCCTGAGTAGCTGGGACTACAGGCACATGCCATCACACCCAACTAATTTTTT TATTTTTTGTAAAGATGAGGGCTATGTTGCCCAGGTTAGTCTTGAACTCCTGGACTGAAG CAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTATAGGCATGAGCCACAGGACCTG GCCCATGGTTTCTTATACAGTCAATGTACAAATGCTCATTTATATTTTGCACAATAATGA AGATAAAAATAACAATTATAGCAACATACAAATATGTACAAAGATTCCAGACAGACTTTG TTTTTTGGCTTATAACAATGTGTAGATACTACACAAAAAATGAGGATGTAATTTTCATTT ACAAGCAAAATGTGACCCAAATCCCTTTTCTTCTTAAAATTGAAAAAAGAAATTCTTGGA AAAACTAATTAGTGACGGCCAAATCTTAAACTATTTTAAATTACCCATGGTTAAACATAG GTGAGTTAAACATGTGCCCTTCCAAATTAAGTTTGCCGTTAAAACATAACATTTGATAAA ACTTCCAAAATAATTATGAGTGGCTTATTCAGTCCTTTGAATCCAGACCCCACTAAAACA ATTAACTTTAAAAGTGATATTTTTAAAACCACCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002895 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002895.2, NP_002886.2 |
| RefSeq Size | 4270 bp |
| RefSeq ORF | 3207 bp |
| Locus ID | 5933 |
| UniProt ID | P28749 |
| Domains | RB_B, RB_A |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Cell cycle, TGF-beta signaling pathway |
| Gene Summary | The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Phosphatidylinositol 3-Kinase/Protein Kinase C-Induced Phosphorylation of Sp1 and p107 Repressor Release Have a Critical Role in Histone Deacetylase Inhibitor-Mediated Depression of Transcription of the Luteinizing Hormone Receptor Gene
,Ying Zhang, Mingjuan Liao, and Maria L. Dufau,
Mol. Cell. Biol.,Sep 2006; 26: 6748 - 6761.
[RBL1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215873 | RBL1 (Myc-DDK-tagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1 |
CNY 10,640.00 |
|
| RC215873L1 | Lenti-ORF clone of RBL1 (Myc-DDK-tagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1 |
CNY 12,540.00 |
|
| RC215873L2 | Lenti-ORF clone of RBL1 (mGFP-tagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1 |
CNY 14,296.00 |
|
| RC215873L3 | Lenti-ORF clone of RBL1 (Myc-DDK-tagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1 |
CNY 12,540.00 |
|
| RC215873L4 | Lenti-ORF clone of RBL1 (mGFP-tagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1 |
CNY 12,540.00 |
|
| RG215873 | RBL1 (tGFP-tagged) - Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 1 |
CNY 13,496.00 |
